Abstract
The administration of porcine somatotropin (pST) to pregnant sows during early gestation (day 10 to 24) induced the formation of significantly more muscle fibres in thesemitendinosus muscle of the fetuses, representing a higher growth capacity of skeletal muscle. The pST-treatment during late pregnancy (day 80 to 94) accelerated the development of the fetus resulting in higher body weights and advanced stage of maturity at birth.
This is a preview of subscription content, log in via an institution to check access.
References
Bassett, N. S., Oliver, M. H., Breier, B. H., and Gluckman, P. D. (1990) The effect of maternal starvation on plasma insulin-like growth factor I concentration in the late gestation ovine fetus.Pediatr. Res. 27:401–404.
Beermann, D. H., Cassens, R. G. and Hausman, G. J. (1978). A second look at fibre type differentiation in porcine skeletal muscle.J. Anim. Sci. 46:125–132.
Dooley, S. L. and Metzger, B. E. (1980) Fetal metabolism and nutrition. In:Gynecology and Obstetrics, (Ed.: Sciarra, J. J.) Hagerstown, Maryland,3:1–15.
Ender, K. and Hartung, J. (1989) Grundlagen zur Erzielung einer Übereinkunft über die Zerlegung. Tagungsber. Akad. Landwirtschwiss.DDR,263:67–72.
Etherton, T. D., Sorensen, M. T., Coleman, M. E. and Chaudhuri, S. (1989) Mechanisms by which porcine somatotropin alters muscle growth and adipose tissue accretion.Proc. Reciprocal Meat Conf. 42:83–89.
Etherton, T. D., Wiggins, J. P., Evock, C. M., Chung, C. S., Rebhun, J. F., Walton, P. E. and Steele, N. C. (1987) Stimulation of pig growth performance by porcine growth hormone: Determination of the dose-response relationship.J. Anim. Sci. 64:433.
Florini, J. R. (1987) Hormonal control of muscle growth.Muscle & Nerve,10:577–598.
Gluckman, P. D. (1986) The regulation of fetal growth. Proc. 43rd Nottingham Easter School in Agric. Sci., Ed.: Butterworths, London, 85–104.
Guth, I. and Samaha, F. J. (1970) Procedure for the histochemical demonstration of actomyosin ATPase.Exp. Neurol. 28:365–367.
Machlin, L. J. (1972) Effect of procine growth hormone on growth and carcass composition of the pig.J. Anim. Sci. 35:794.
Magri, K. A., Ewton, D. Z. and Florini, J. R. (1991) The role of the IGFs in myogenic differentiation. In:Molecular Biology and Physiology of Insulin and Insulin-like Growth Factors, (Ed.: M. K. Raizada, D. LeRoith) Plenum Press, New York, 57–76.
Milner, R. D. G. and Hill, D. J. (1984) Fetal growth control: the role of insulin and related peptides. Clin. Endocrinol.21:415–433.
Munro, H. N. and Fleck, A. (1966) Recent developments in the measurement of nucleoic acids in biological materials.Analyst 91:78–88.
Peterson, G. L. (1977) A simplication of protein protein assay method of Lowry which is more applicable.Anal Biochem. 83:346–356.
Rehfeldt, Ch., Fiedler, I. and Wegner, J. (1987) Veränderungen der Mikrostruktur des Muskelgewebes bei Labormäusen, Rindern und Schweinen.Z. mikrosk. anat. Forsch. 101:669–680.
Richards, G. M. (1974) Modifications of the diphenylamine reaction giving increased sensivity and simplicity in the estimation of DNA.Anal. Biochem. 57:369–376.
Robinson, J. S., Kingston, E. J. and Thornburn, G. D. (1978). Physiological and endocrine factors in human fetal growth.Postgrad. Med. J. (Suppl. 1)54:51.
Romeis, B. (1989) Mikroskopische Technik, Ed.: Urban & Schwarzenberg, München. 697 pp.
Seidemann, S. C., Cohen, S. H. and Schollmeyer, J. V. (1984) Some factors influencing ante-mortem changes in muscle: a brief review.Food Microstructure 3:127–132.
Spencer, G. C. G., Hill, D. J., Garssen, G. T., MacDonald, A. A. and Colenbrander, B. (1983) Somatomedin activity and growth hormone levels in body fluids of the fetal pig: effects of chronic hyperinsuliemia.J. Endocrinol. 96:107–114.
Stickland, N. C. (1993) Personal communication.
Wigmore, P. M. C. and Stickland, N. C. 1983 DNA, RNA and protein in skeletal muscle of large and small pig fetuses.Growth 47:67–76.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rehfeldt, C., Fiedler, I., Weikard, R. et al. It is possible to increase skeletal muscle fibre numberin utero . Biosci Rep 13, 213–220 (1993). https://doi.org/10.1007/BF01123503
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01123503