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Annexins—New family of Ca2+-regulated-phospholipid binding protein

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Abstract

Calcium and phospholipid binding proteins have been identified and localized by immunocytochemistry in a wide range of cells and tissues. Two of these proteins (calpactins) also bind F-actin and are substrates for tyrosine kinases. The similar membrane-binding properties of these molecules arise from conserved amino acid sequences and a model is proposed for the tertiary structure of a common calcium and phospholipid binding domain.

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References

  • Alitalo, K., Ralston, R. R. and Keski-Oja, J. (1984).Exp. Cell. Res. 150:177.

    Google Scholar 

  • Blackwell, G. J., Carnuccio, R., Di Rosa, M., Flower, R. J., Parente, L. and Persico, P. (1980).Nature 287:147–149.

    Google Scholar 

  • Blackwell, G. J., Carnuccio, R., Di Rose, M., Flower, R. J., Langham, S. J., Paente, L., Persico, P., Russell-Smith, N. C. and Stone, D. (1982).J. Pharmac. 76:185–194.

    Google Scholar 

  • Braslau, D. L., Ringo, D. L. and Rocha, V. (1984).Exp. Cell. Res. 155:213–221.

    Google Scholar 

  • Cooper, J. A. and Hunter, T. (1983).Curr. Topics Microbiol. Immunol. 107:125–161.

    Google Scholar 

  • Creutz, C. E., Dowing, L. G., Sando, J. J., Villar-Plasi, C., Whipple, J. H. and Zaks, W. J. (1983).J. Biol. Chem. 258:14664–14674.

    Google Scholar 

  • Creutz, C. E., Pazoles, C. J. and Pollard, H. B. (1978).J. Biol. Chem. 253:2858–2866.

    Google Scholar 

  • Davidson, F. F., Dennis, E. A., Powell, M. and Glenney, J. R. (1987).J. Biol. Chem. 262:1698–1705.

    Google Scholar 

  • Davis, A. A. and Crumpton, M. J. (1985).Biochem. Biophys. Res. Commun. 128:571–577.

    Google Scholar 

  • Elsbach, P., Weiss, J., Franson, R. C., Beckerdite-Quagliata, S., Schneider, A. and Harris, L. (1979).J. Biol. Chem. 254:11000–11009.

    Google Scholar 

  • Fava, R. A. and Cohen S. (1984).J. Biol. Chem. 259:2636–2645.

    Google Scholar 

  • Fiedler, W. and Walker, J. H. (1985).Eur. J. Cell. Biol. 38:34–41.

    Google Scholar 

  • Flower, R. J., Wood, J. N. and Parente, L. (1984).Adv. Inflamm. Res. 7:61–69.

    Google Scholar 

  • Geisow, M. J. (1986).FEBS Lett. 203:99–102.

    Google Scholar 

  • Geisow, M. J. and Walker, J. H. (1986).Trends Biochem. Sci. 11:420–423.

    Google Scholar 

  • Geisow, M. J. and Burgoyne, E. D. (1982).J. Neurochem. 38:1735–1741.

    Google Scholar 

  • Geisow, M. J., Childs, J., Dash, B., Harris, A., Panayotou, G., Südhof, T. and Walker, J. H. (1984).EMBO J. 3:2969–2974.

    Google Scholar 

  • Geisow, M. J., Fritsche, U., Hexham, J. M., Dash, B. and Johnson, T. (1986).Nature 320:636–638.

    Google Scholar 

  • Gerke, V. and Weber, K. (1984).EMBO J. 3:227–233.

    Google Scholar 

  • Gerke, V. and Weber, K. (1985a).J. Biol. Chem. 280:1688–1695.

    Google Scholar 

  • Gerke, V. and Weber, K. (1985b).EMBO J. 4:2917–2920.

    Google Scholar 

  • Glenney, J. R. (1985).FEBS Lett. 192:79–82.

    Google Scholar 

  • Glenney, J. R. (1986a).J. Biol. Chem. 261:7247–7252.

    Google Scholar 

  • Glenney, J. R. (1986b).Proc. Natl. Acad. Sci. 83:4258–4262.

    Google Scholar 

  • Glenney, J. R. (1986c).Exp. Cell. Res. 162:183–190.

    Google Scholar 

  • Glenney, J. R. and Tack, B. F. (1985).Proc. Natl. Acad. Sci. 82:7884–7888.

    Google Scholar 

  • Gould, K. L., Woodgett, J. R., Isacke, C. M. and Hunter, T. (1986).Mol. and Cell. Biol. 6:2738–2744.

    Google Scholar 

  • Haigler, H. T., Schlaepfer, D. D. and Burgess, W. H. (1987).J. Biol. Chem. in press.

  • Hexham, J. M., Totty, N. F., Waterfield, M. D. and Crumpton, M. J. (1986).Biochem. Biophys. Res. Commun. 134:248–254.

    Google Scholar 

  • Huang, K.-S. et al. (1986).Cell 46:191–199.

    Google Scholar 

  • Hunter, T. (1986).Cell 4:201–212.

    Google Scholar 

  • Hunter, T. and Sefton, B. M. (1982). In:Molecular Actions of Toxins, Viruses and Interferon (P. Cohen and S. Van Heyningen (Eds.), Elsevier/North Holland, New York, pp. 337–370.

    Google Scholar 

  • Johnsson, N., Vandekerkhove, J., Van Damme, J., and Weber, K. (1986).FEBS Lett. 198:361–364.

    Google Scholar 

  • Keski-Oja, J. and Alitalo, K. (1985).Exp. Cell. Res. 158:86–94.

    Google Scholar 

  • Khanna, N. C., Tokada, M., Chong, S. M. and Waisman, D. M. (1986).Biochem. Biophys. Res. Commun. 137:397–403.

    Google Scholar 

  • Kretsinger, R. H. A. (1980).CRC Crit. Rev. Biochem. 8:86–94.

    Google Scholar 

  • Kristensen, T., Saris, C. J. M., Hunter, T., Hicks, L. J., Noonan, D. J., Glenney, J. R. and Tack, B. F. (1986).Biochemistry 25:4497–4503.

    Google Scholar 

  • Moore, P. B. and Dedman, J. R. (1982).J. Biol. Chem. 257:9663–9667.

    Google Scholar 

  • Owens, R. J. and Crumpton, M. J. (1984).Biochem. Essays 1:61–63.

    Google Scholar 

  • Owens, R. J., Gallagher, C. J. and Crumpton, M. J. (1984).EMBO J. 3:945–952.

    Google Scholar 

  • Pepinsky, R. B. and Sinclair, L. K. (1986).Nature 321:81–84.

    Google Scholar 

  • Pollard, H. B. and Scott, J. H.FEBS Lett. 150:201–206.

  • Reaymaekers, L., Whytack, F. and Casteels, R. (1985).Biochem. Biophys. Res. Commun. 132:526–532.

    Google Scholar 

  • Saris, C. J. M., Tack, B. F., Kristensen, T., Glenney, J. R. and Hunter, T. (1986).Cell 4:201–212.

    Google Scholar 

  • Schlaepfer, D. D. and Haigler, H. T. (1987).J. Biol. Chem. in press.

  • Südhof, T. C. (1984).Biochem. Biophys. Res. Commun. 123:100–107.

    Google Scholar 

  • Südhof, T. C., Walker, J. H. and Ocbrocki, J. (1982).EMBO J. 1:1167–1170.

    Google Scholar 

  • Südhof, T. C., Ebbecke, M., Walker, J. H., Fritsche, U. and Boustead, C. (1984).Biochemistry 23:1103–1109.

    Google Scholar 

  • Südhof, T. C., Walker, J. H. and Fritsche, U. (1985).J. Neurochem. 44:1302–1307.

    Google Scholar 

  • Szebenyi, D. M. E., Obendorf, S. K. and Moffat, K. (1981).Nature 294:327–331.

    Google Scholar 

  • Taylor, V. V. and Geisow, M. J. (1987).Protein Engineering 3 (in press).

  • Tufty, R. M. and Kretsinger, R. H. (1975).Science 187:167–169.

    Google Scholar 

  • Utsumi, K., Sato, E., Okimasu, E., Miyahara, M. and Takahasi, R. (1986).FEBS Lett. 201:277–281.

    Google Scholar 

  • Valentine-Braun, K. A., Northrup, J. K. and Hollenberg, M. D. (1986).Proc. Natl. Acad. Sci. USA 83:236–240.

    Google Scholar 

  • Walker, J. H. (1982).J. Neurochem. 39:815–823.

    Google Scholar 

  • Wallner, B. P. et al. (1986).Nature 320:77–81.

    Google Scholar 

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Authors and Affiliations

  1. Protein Chemistry, Delta Biotechnology Ltd., Castle Boulevard, NG7 1FD, Nottingham

    Michael J. Geisow

  2. Biochemistry Department, Leeds University, Leeds, UK

    John H. Walker & Catherine Boustead

  3. Department of Crystallography, Birkbeck College, Malet Street, NW1, London

    Willie Taylor

Authors
  1. Michael J. Geisow
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  2. John H. Walker
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  3. Catherine Boustead
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  4. Willie Taylor
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Geisow, M.J., Walker, J.H., Boustead, C. et al. Annexins—New family of Ca2+-regulated-phospholipid binding protein. Biosci Rep 7, 289–298 (1987). https://doi.org/10.1007/BF01121450

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  • DOI: https://doi.org/10.1007/BF01121450

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