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Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

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Bioscience Reports

Abstract

Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

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References

  • Acuto O, Hussey R, Fitzgerald K, Protentis S, Meuer S, Schlossman S & Reinherz E (1983) Cell34, 717–726.

    PubMed  Google Scholar 

  • Ando I, Hariri G, Wallace D & Beverley P (1985) Eur. J. Immunol.15, 196–199.

    PubMed  Google Scholar 

  • Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF & Ziegler A (1978) Cell14, 9–20.

    PubMed  Google Scholar 

  • Beverley PCL & Callard RE (1981) Euro. J. Immunol.11, 329–334.

    Google Scholar 

  • Borst J, Alexander S, Elder J & Terhorst C (1983) J. Biol. Chem.258, 5135–5141.

    PubMed  Google Scholar 

  • Boylston AW, Goldin RD & Moore CS (1984) Eur. J. Immunol.14, 273–275.

    PubMed  Google Scholar 

  • Brenner MB, Trowbridge IS & Strominger JL (1985) Cell40, 183–190.

    PubMed  Google Scholar 

  • Buchnea D (1971) Lipids6, 734–739.

    Google Scholar 

  • Cantrell DA, Davies AA & Crumpton MJ (1985) Proc. Natl. Acad. Sci. U.S.A., in press.

  • Delia D, Greaves MF, Newman RA, Sutherland DR, Minowada J, Kung P & Goldstein G (1982) Int. J. Cancer29, 23–31.

    PubMed  Google Scholar 

  • Grunberger G & Gordon P (1982) Am. J. Physiol.243, E319-E324.

    PubMed  Google Scholar 

  • Haskins K, Kubo R, White J, Pigeon M, Kappler J & Marrack P (1983) J. Exp. Med.157, 1149–1169.

    PubMed  Google Scholar 

  • Jacobs S, Sahyoun NE, Saltiel AR & Cuatrecasas P (1983) Proc. Natl. Acad. Sci. U.S.A.80, 6211–6213.

    PubMed  Google Scholar 

  • Kanellopoulos JM, Wigglesworth NM, Owen MJ & Crumpton MJ (1983) EMBO J.2, 1807–1814.

    PubMed  Google Scholar 

  • McCaffrey PG, Friedman B & Rosner MR (1984) J. Biol. Chem.259, 12502–12507.

    PubMed  Google Scholar 

  • Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon J, Schlossman SF & Reinherz EL (1983a) J. Exp. Med.157, 705–719.

    PubMed  Google Scholar 

  • Meuer S, Acuto O, Hussey R, Hodgdon J, Fitzgerald K, Schlossman S & Reinherz E (1983b) Nature (Lond.)303, 808–810.

    Google Scholar 

  • Meuer S, Hodgdon J, Hussey R, Protentis J, Schlossman S and Reinherz E (1983c) J. Exp. Med.158, 988–993.

    PubMed  Google Scholar 

  • Monos DS & Cooper HL (1983)131, 341–346.

  • Nishizuka Y (1984) Nature (Lond.)308, 693–698.

    Google Scholar 

  • Reinherz EL, Meuer S, Fitzgerald KA, Hussey RE, Levine H & Schlossman S (1982) Cell30, 735–743.

    PubMed  Google Scholar 

  • Rozengurt E, Rodriguez-Pena M & Smith KA (1983) Proc. Natl. Acad. Sci. U.S.A.80, 7244–7248.

    PubMed  Google Scholar 

  • Shoyab M, De Larco JE & Todaro GJ (1979) Nature (Lond.)279, 387–391.

    Google Scholar 

  • Stratford May W, Jacobs S & Cuatrecasas P (1984) Proc. Natl. Acad. Sci. U.S.A.81, 2016–2020.

    PubMed  Google Scholar 

  • Yasushi I, Yoshimi T, Kikkawa U & Nishizuka Y (1980) Biochem. Biophys. Res. Comm.96, 180–187.

    PubMed  Google Scholar 

  • Zanders E, Lamb J, Feldman M, Green N & Beverley P (1983) Nature (Lond.)303, 625–627.

    Google Scholar 

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A 3PX, London, UK

    Adelina A. Davies, Doreen A. Cantrell & Michael J. Crumpton

Authors
  1. Adelina A. Davies
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  2. Doreen A. Cantrell
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  3. Michael J. Crumpton
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Davies, A.A., Cantrell, D.A. & Crumpton, M.J. Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes. Biosci Rep 5, 867–876 (1985). https://doi.org/10.1007/BF01119898

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  • DOI: https://doi.org/10.1007/BF01119898

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