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The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes

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Bioscience Reports

Abstract

It is shown that the time-course of incorporation of radioactivity from [3-14C]serine into nucleic acids parallels DNA synthesis following mitogenic stimulation of human peripheral blood lymphocytes by phytohaemagglutinin (PHA). The activity of serine hydroxymethyltransferase was elevated about four-fold in PHA-stimulated lymphocytes compared to that in unstimulated control ceils. It is suggested that lymphocytes, in common with other proliferating cell systems:, may synthesize serine de novo for utilization in pathways of nucleotide biosynthesis following mitogenic stim--ulation.

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Authors and Affiliations

  1. Department of Biochemistry, University of Surrey, GU2 5XH, Guildford, UK

    Hans-Georg Eichler, Ron Hubbard & Keith Snell

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  1. Hans-Georg Eichler
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  2. Ron Hubbard
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  3. Keith Snell
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Eichler, HG., Hubbard, R. & Snell, K. The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes. Biosci Rep 1, 101–106 (1981). https://doi.org/10.1007/BF01117006

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  • DOI: https://doi.org/10.1007/BF01117006

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