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Heat shock proteins induce pores in membranes

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Abstract

Human heat shock protein (hsp) 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide, byS. aureus α toxin or by diphtheria toxin. Hsp 70 and groEL, as well as two mycobacterial homologues hsp 71 and hsp 65, induce ion conducting pores across planar lipid bilayers at low or neutral pH. It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells.

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Authors and Affiliations

  1. Department of Cellular and Molecular Sciences, St George's Hospital Medical School, SW17 ORE, London

    G. M. Alder, C. L. Bashford & C. A. Pasternak

  2. Department of Surgery, St George's Hospital Medical School, SW17 ORE, London

    B. M. Austen

  3. Department of Biochemistry, University of Dundee, DD1 4HN, Dundee

    A. Mehlert

Authors
  1. G. M. Alder
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  2. B. M. Austen
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  3. C. L. Bashford
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  4. A. Mehlert
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  5. C. A. Pasternak
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Alder, G.M., Austen, B.M., Bashford, C.L. et al. Heat shock proteins induce pores in membranes. Biosci Rep 10, 509–518 (1990). https://doi.org/10.1007/BF01116611

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  • DOI: https://doi.org/10.1007/BF01116611

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