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The mechanisms by which vasoactive intestinal peptide (VIP) and thyrotropin releasing hormone (TRH) stimulate prolactin release from pituitary cells

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Abstract

The effect of vasoactive intestinal peptide (VIP) on prolactin (PRL) secretion from pituitary cells is reviewed and compared to the effect of thyrotropin releasing hormone (TRH). These two peptides induced different secretion profiles from parafused lactotrophs in culture. TRH was found to increase PRL secretion within 4 s and induced a biphasic secretion pattern, while VIP induced a monophasic secretion pattern after a lag time of 45–60 s.

The secretion profiles are compared to changes in adenylate cyclase activity, production of inositol polyphosphates, changes in intracellular calcium concentrations and changes in electrophysiological properties of the cell membrane.

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Abbreviations

AC:

adenylate cyclase

DG:

diacyglycerol

GH:

growth hormone

GTP:

guanosine trisphosphate

Gi :

GTP binding proteins that mediate inhibition of adenylate cyclase and that are pertussis toxin sensitive

Gs :

GTP binding protein that mediates stimulation of adenylate cyclase

GH cells:

clonal rat pituitary tumor cells producing PRL and/or growth hormone

GH3 GH4C1 and GH4B6:

subclones of GH cells

PKA:

protein kinase A

PKC:

protein kinase C

PLC:

phospholipase C

PRL:

prolactin

TPA:

12-O-tetradecanoyl phorbol 13-acetate

TRH:

thyrotropin releasing hormone

VIP:

vasoactive intestinal peptide

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Authors and Affiliations

  1. Hormone Laboratory, Aker Hospital, N-0514, Oslo, Norway

    Trine Bjøro, Bjørn Chr. Østberg, Peter Torjesen & Egil Haug

  2. Department of Biology, University of Oslo, N-0316, Oslo, Norway

    Olav Sand

  3. Institute of Medical Biochemistry, University of Oslo, N-0316, Oslo, Norway

    Jan O. Gordeladze & Kaare M. Gautvik

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  1. Trine Bjøro
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  2. Olav Sand
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Bjøro, T., Sand, O., Østberg, B.C. et al. The mechanisms by which vasoactive intestinal peptide (VIP) and thyrotropin releasing hormone (TRH) stimulate prolactin release from pituitary cells. Biosci Rep 10, 189–199 (1990). https://doi.org/10.1007/BF01116578

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