Abstract
A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.
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de Kruijff, B. Cholesterol as a target for toxins. Biosci Rep 10, 127–130 (1990). https://doi.org/10.1007/BF01116571
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DOI: https://doi.org/10.1007/BF01116571