Skip to main content
SpringerLink
Log in

Changes in lipoprotein binding and uptake by hepatocytes during rat liver regeneration

  • Short Papers
  • Published:
Bioscience Reports

Abstract

The binding and uptake of cholesterol enriched lipoproteins by isolated hepatocytes was decreased at 16 hours after partial hepatectomy, with a tendency to return to control values as the regeneration proceeds. The number of lipoprotein binding sites of total cellular membranes remained similar to control at 16 and 24 hours. The plasma lipoprotein pattern, determined by electrophoretic analysis, showed a lower per cent of very low density lipoproteins (VLDL) and a higher per cent of low density lipoproteins (LDL) at 16 and 24 hours post-partial hepatectomy. At these times, plasma lecithin: cholesterol acyltransferase (LCAT) activity was decreased. It is intriguing to suggest that the regenerating liver could regulated the blood lipoprotein pattern and the uptake of lipoproteins by modulating the surface expression of the receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Arbeeny, C. M. and Rifici, V. A. (1984)J. Biol. Chem. 259:9662–9666.

    Google Scholar 

  • Barghava, G. and Levine, W. G. (1980)Gastroenterol. 79:1005.

    Google Scholar 

  • Barnard, G. F., Erickson, S. K. and Cooper, A. D. (1984)J. Clin. Invest. 74:173–184.

    Google Scholar 

  • Basu, S. S., Goldstein, J. L. and Brown, M. S. (1978)J. Biol. Chem. 253:3852–3856.

    Google Scholar 

  • Brown, M. S. and Goldstein, J. L. (1983)J. Clin. Invest. 72:743–747.

    Google Scholar 

  • Bruscalupi, G., Curatola, G., Lenaz, G., Leoni, S., Mangiantini, M. T., Mazzanti, L., Spagnuolo, S. and Trentalance, A. (1980)Biochim. Biophys. Acta 597:263–273.

    Google Scholar 

  • Bruscalupi, G., Giordano, C., Leoni, S., Mangiantini, M. T., Spagnuolo, S. and Trentalance, A. (1987)Eur. J. Physiol. 410:S7.

    Google Scholar 

  • Bucher, N. L. R. (1963)Int. Rev. Cytol. 15:245–290.

    Google Scholar 

  • Bucher, N. L. R. and Berkeley, P. (1975) In “Cell Cycle in Malignancy and Immunity” (Hampton, J. C., ed.), USERDA Techn. Inf. Center, pp. 67–75.

  • Chao, Y., Windler, E. E., Chen, C. and Havel, R. J. (1979)J. Biol. Chem. 254:11360–11366.

    Google Scholar 

  • Chen, C. and Albers, J. J. (1982)J. Lipid Res. 23:680–691.

    Google Scholar 

  • Cooper, A. D. and Yu, P. Y. S. (1978)J. Lipid Res. 19:635–643.

    Google Scholar 

  • Fielding, P. E. and Fielding, C. J. (1980)Proc. Natl. Acad. Sci. USA 77:3327–3330.

    Google Scholar 

  • Fraker, P. J. and Speck, J. C. (1978)Biochem. Biophys. Res. Commun. 80:849–857.

    Google Scholar 

  • Higgins, G. and Anderson, R. M. (1931)Archs. Pathol. 12:186–202.

    Google Scholar 

  • Howard, D. J., Stockert, R. J. and Morell, A. G. (1982)J. Biol. Chem. 257:2856–2858.

    Google Scholar 

  • Hui, D. Y., Innerarity, T. L. and Maley, R. W. (1983)J. Biol. Chem. 259:860–869.

    Google Scholar 

  • Jones, A. L., Hradek, G. T., Hornik, C., Renaud, G., Windler, E. E. T. and Havel, R. K. (1984)J. Lipid Res. 25:1151–1158.

    Google Scholar 

  • Kelly, R. B. (1987)Nature 326:14–15.

    Google Scholar 

  • Kingsley, D. M., Kozarsky, K. F., Segal, M. and Krieger, M. (1986)J. Cell Biol. 102:1576–1585.

    Google Scholar 

  • Koelz, H. R., Sherril, B. C., Turley, S. D. and Dietschy, J. M. (1982)J. Biol. Chem. 257:8061–8072.

    Google Scholar 

  • Kovanen, P. T., Basu, S. K., Goldstein, J. L. and Brown, M. S. (1979)Endocrinol. 104:610–616.

    Google Scholar 

  • Kovanen, P. T., Brown, M. S., Basu, S. K., Billheimer, D. W. and Goldstein, J. L. (1981)Proc. Natl. Acad. Sci. USA 78:1396–1400.

    Google Scholar 

  • Leoni, S., Spagnuolo, S., Mangiantini, M. T. and Trentalance, A. (1982)Cell. Mol. Biol. 28:131–134.

    Google Scholar 

  • Leoni, S., Marino, M., Spagnuolo, S., Trentalance, A. and Mangiantini, M. T. (1987)Med. Sci. Res. 15:1333–1334.

    Google Scholar 

  • Loeb, J. N. and Rosner, W. (1979)Endocrinol. 104:1003–1006.

    Google Scholar 

  • Lowry, O. H., Rosebrough, N. J. Farr, A. L. and Randall, R. J. (1951)J. Biol. Chem. 193:265–275.

    Google Scholar 

  • Mahley, R. H. and Holcombe, K. S. (1977)J. Lipid Res. 18:314–326.

    Google Scholar 

  • Marino, M., Bruscalupi, G., Spagnuolo, S., Leoni, S., Mangiantini, M. T., Trentalance, A. and Hemming, F. W. (1986)Biosci. Rep. 6:409–412.

    Google Scholar 

  • Marsh, J. B. and Sparks, C. E. (1979)J. Clin. Invest. 64:1229–1237.

    Google Scholar 

  • Moldeus, P., Hogberg, J. and Horrhenius, S. (1978)Meth. Enzymol. 52:60–71.

    Google Scholar 

  • Naito, H. K., Wada, M., Ehart, L. A. and Lewis, L. A. (1973)Clin. Chem. 19:228–234.

    Google Scholar 

  • Narayan, K. A., Mary, G. E. S. and Kummerow, F. A. (1968)Proc. Soc. Exp. Biol Med. 129:6–12.

    Google Scholar 

  • Schneider, W. J., Beisiegel, U., Goldstein, J. L. and Brown, M. S. (1982)J. Biol. Chem. 257:2664–2673.

    Google Scholar 

  • Tei, I., Makino, Y., Kadofuku, T., Kanamaru, I. and Konno, K. (1984)Biochem. Biophys. Res. Comm. 121:717–721.

    Google Scholar 

  • Trentalance, A., Leoni, S., Mangiantini, M. T., Spagnuolo, S., Feingold, K., Hughes-Fulford, M., Siperstein, M., Cooper, A. D. and Erickson, S. K. (1984)Biochim. Biophys. Acta 794:142–151.

    Google Scholar 

  • Van Tol, A., Van Gent, T., Van't Hooft, F.M. and Vlaspolder, F. (1978)Atherosclerosis 29:439–448.

    Google Scholar 

  • Van Tol, A., Van't Hooft, F. M. and Van Gent, T. (1978)Atherosclerosis 29:449–457.

    Google Scholar 

  • Wileman, T., Harding, C. and Stahl, P. (1985)Biochem. J. 232:1–14.

    Google Scholar 

  • Windler, E. E. T., Kovanen, P. T., Chao, y. S., Brown, M. S., Havel, R. J. and Goldstein, J. L. (1980)J. Biol. Chem. 255:10464–10471.

    Google Scholar 

  • Wondergem, R. and Harder, D. R. (1980)J. Cell. Physiol. 102:193–197.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Biologia Cellulare e dello Sviluppo, Universita' di Roma I “La Sapienza”, Piazzale Aldo Moro 5, 00185, Roma, Italy

    A. Trentalance, G. Bruscalupi, L. Conti Devirgiliis, S. Leoni, M. T. Mangiantini, L. Rossini & S. Spagnuolo

  2. Department of Medicine, University of California, San Francisco, California, USA

    S. K. Erickson

  3. Veterans Administration Medical Center, San Francisco, California, USA

    S. K. Erickson

Authors
  1. A. Trentalance
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Bruscalupi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Conti Devirgiliis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Leoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. T. Mangiantini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. Rossini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. Spagnuolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. K. Erickson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trentalance, A., Bruscalupi, G., Devirgiliis, L.C. et al. Changes in lipoprotein binding and uptake by hepatocytes during rat liver regeneration. Biosci Rep 9, 231–241 (1989). https://doi.org/10.1007/BF01116000

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01116000

Key Words

Search

Navigation