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High liver lipoprotein lipase activity in hyperlipemic developing rats from undernourished pregnant mothers

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Abstract

To study the potential relationship between circulating triacylglycerol (TAG) levels and lipoprotein lipase (LPL) activity in the newborn rat liver, pups from undernourished or normal control mothers were nursed by normal dams, and studied at 0, 1, 15 or 30 days of age. Plasma TAG levels and liver TAG concentration increased more in pups from undernourished mothers than they did in controls. At birth, liver LPL activity was similarly high in both groups but, whereas in controls it decreased progressively after birth, in pups from undernourished mothers it remained stable until 15 days of age. Results suggest that the hypertriglyceridemia present in pups from undernourished mothers may be responsible for the sustained high LPL activity in their liver which may enhance the hepatic uptake of circulating TAG.

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Authors and Affiliations

  1. Departamento de Bioquímica y Fisiología, Facultad de Biologia, Universidad de Barcelona, Avda Diagonal 645, 08028, Barcelona, Spain

    D. López-Tejero & M. Llobera

  2. Departamento de Investigación, Centro Ramón y Cajal, Ctra. de Colmenar Km 9, 28031, Madrid, Spain

    E. Herrera

Authors
  1. D. López-Tejero
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  2. M. Llobera
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  3. E. Herrera
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López-Tejero, D., Llobera, M. & Herrera, E. High liver lipoprotein lipase activity in hyperlipemic developing rats from undernourished pregnant mothers. Biosci Rep 8, 309–314 (1988). https://doi.org/10.1007/BF01115221

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  • DOI: https://doi.org/10.1007/BF01115221

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