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The metabolism of acetone in the pregnant rat

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Abstract

The administration of a single dose of acetone (100 mg/kg bw) to virgin and 21-day pregnant rats resulted in the appearance of relatively high concentrations of 1,2-propanediol, acetol and methylglyoxal in plasma and liver. In the fetuses no methylglyoxal was detectable. The acetone metabolism curves tend to indicate that the capacity for acetone disposal may be enhanced in the 48 hr-fasted pregnant rat, thus enabling the animal to re-use acetone metabolically, possibly for accelerated gluconeogenesis.

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Authors and Affiliations

  1. Dept. Bioquímica i Fisiologia, Unitat de Bioquímica i Biologia Molecular B, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071, Barcelona, Spain

    J. Peinado, F. J. López-Soriano & J. M. Argilés

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  1. J. Peinado
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  2. F. J. López-Soriano
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  3. J. M. Argilés
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Peinado, J., López-Soriano, F.J. & Argilés, J.M. The metabolism of acetone in the pregnant rat. Biosci Rep 6, 983–989 (1986). https://doi.org/10.1007/BF01114975

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  • DOI: https://doi.org/10.1007/BF01114975

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