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Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans

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Bioscience Reports

Abstract

Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, were each shown to inhibit glucose-stimulated insulin secretion from isolated rat islets of Langerhans. These findings suggest that the dynamic regulation of microtubule polymerization-depolymerization in pancreatic B ceils may be important for insulin secretion via the microtubule-microfilamentous system.

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References

  • de Brabander MJ, Aerts RML, Borges FGM & Janssen PAJ (1976) Cancer Research36, 905–916.

    Google Scholar 

  • de Brabander M, Gauens G, Nuydens R, Willebrords R & De May J (1980) Proc. Natl. Acad. Sci. U.S.A.78, 5608–5612.

    Google Scholar 

  • Gey GO & Gey MK (1936) Amer. J. Cancer27, 45–76.

    Google Scholar 

  • Howell SL & Taylor KW (1966) Biochim. Biophys. Acta130, 519–521.

    Google Scholar 

  • Howell SL & Tyhurst M (1982) Diabetologia22, 301–308.

    Google Scholar 

  • Hunter WM & Greenwood FC (1962) Nature (Lond.)194, 495–496.

    Google Scholar 

  • Schiff PB, Grant J and Horwitz SB (1979) Nature277, 665–667

    Google Scholar 

  • Schiff PB & Horwitz SB (1980) Proc. Natl. Acad. Sci. U.S.A.77, 1561–1565.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology, Queen Elizabeth College, University of London, Campden Hill Road, W8 7AH, London

    S. L. Howell, C. S. Hii, S. Shaikh & M. Tyhurst

Authors
  1. S. L. Howell
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  2. C. S. Hii
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  3. S. Shaikh
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  4. M. Tyhurst
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Howell, S.L., Hii, C.S., Shaikh, S. et al. Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans. Biosci Rep 2, 795–801 (1982). https://doi.org/10.1007/BF01114939

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  • DOI: https://doi.org/10.1007/BF01114939

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