Summary
1. A patient with insulin resistant diabetes mellitus has been described in detail with emphasis upon the time relationship between prior insulin therapy for mental illness and the subsequent development of overt diabetes. 2. The localization of the insulin antibodies in the γg-globulins with some extension into the region of γa has been delineated. 3. The possible relationship between the immunologic responsiveness of the patient and the eventual manifestation of the disease is discussed.
Résumé
1. Un cas de diabète insulino-résistant est présenté en détail et l'attention attirée sur le rapport chronologique entre le début du diabète et une série de traitements antérieurs à l'insulino-choc. 2. Les anticorps anti-insuline ont été localisés dans les γ-globulines par l'emploi consécutif d'électrophorèse et de filtration sur Sephadex. La majorité des anticorps anti-insuline s'est révélée être des globulines γg, avec un débordement important sur la région des globulines γa. 3. La relation pathogénique possible entre la réaction immunologique de la malade et la manifestation du diabète est considérée.
Zusammenfassung
1. Ein Fall von insulinresistentem Diabetes mellitus bei einer Patientin wird ausführlich beschrieben. Das Verhältnis zwischen einer früheren Insulinbehandlung aus psychiatrischer Indikation und dem späterem Auftreten von manifestem Diabetes wird besonders berücksichtigt. 2. Die Lokalisierung der Insulinantikörper in der γg-Globulinfraktion mit Übergang auf die γa Fraktion wird beschrieben. 3. Der mögliche Zusammenhang zwischen der Immunisierung der Patientin und dem Manifestwerden der Krankheit wird diskutiert.
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Cerasi, E., Hogeman, O., Luft, R. et al. Insulin antibodies: Description of specific serum protein localization in a patient with insulin resistant diabetes. Diabetologia 2, 45–51 (1966). https://doi.org/10.1007/BF01106973
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DOI: https://doi.org/10.1007/BF01106973