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Prophylactic endovascular radiotherapy to prevent intimal hyperplasia after stent implantation in femoropopliteal arteries

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Abstract

Purpose: Recurrent stenosis or occlusion by intimal hyperplasia occurs in up to 40% of patients with tantalum stent implantations in femoropopliteal arteries and greatly restricts their usefulness. We evaluated the effect of prophylactic endovascular radiotherapy on stenosed/occluded\ stents.

Methods: We investigated prophylactic endovascular radiotherapy with a surface dose of 12 Gy using an iridium 192 source as a means to reduce or eliminate recurrent stenosis in 4 patients with stenosed/occluded stents, 6–8 months after the original implantation. Confirmatory diagnostic atherectomy, PTA or laser recanalization and endovascular radiotherapy were performed.

Results: None of the four has developed recurrent obstruction within 23 to 30 months after this treatment, which up to now shows no short-term or long-term complications.

Conclusion: We conclude that this limited experience is promising enough to warrant further study.

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Authors and Affiliations

  1. Department of Radiology, J. W. Goethe University Hospital, Theodor Stern Kai 7, No. 23A, D-60590, Frankfurt am Main, Germany

    Dieter Liermann M.D., Jürgen Kollath & Gerd Strassmann

  2. Department of Radiotherapy, J. W. Goethe University Hospital, Theodor Stern Kai 7, No. 23A, D-60590, Frankfurt am Main, Germany

    Heinz D. Bottcher & Bernd Schopohl

  3. Department of Radiology, Diakonissen Hospital Karlsruhe-Rüppurr, Diakonissen-Straße 28, D-76199, Karlsruhe, Germany

    Ernst-P. Strecker

  4. Department of Angiology, J. W. Goethe University Hospital, Theodor Stern Kai 7, No. 23A, D-60590, Frankfurt am Main, Germany

    Karl H. Breddin

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  1. Dieter Liermann M.D.
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Liermann, D., Bottcher, H.D., Kollath, J. et al. Prophylactic endovascular radiotherapy to prevent intimal hyperplasia after stent implantation in femoropopliteal arteries. Cardiovasc Intervent Radiol 17, 12–16 (1994). https://doi.org/10.1007/BF01102065

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