Abstract
Purpose: The aim of the present study was to assess the efficacy of transjugular intrahepatic portosystemic shunts (TIPS) in 45 patients with cirrhosis during a mean follow-up of 7 months.
Methods: Forty-five consecutive patients treated by TIPS and who had been followed for at least 6 months after TIPS or until death, were included. Mean follow-up was 7.2±5.0 months. Shunt patency was assessed at 1 week and 1 month, then every 3 months after the procedure by Doppler US and angiography whenever needed.
Results: Thirty-six patients had been stented for refractory bleeding from ruptured esophagogastric varices. Of these, 8 patients (22%) rebled, 7 of whom were treated by a second shunt. Nine patients were treated for refractory ascites. Three patients had recurrent ascites due to shunt obstruction. All were treated by a second shunt which occluded in 2 patients. As a whole, 14 (31.1%) patients developed shunt obstruction within a mean of 120±136 days, 4 of whom remained asymptomatic. Other complications were septicemia byStaphylococcus aureus in 1 patient, transient encephalopathy in 9 patients, and disseminated intravascular coagulation in 1 patient.
Conclusion: TIPS appears to be a relatively safe and effective technique in treating complications of portal hypertension in patients with cirrhosis. Shunt obstruction in 31% of our patients probably represents the most important limitation of this technique.
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References
Richter GM, Noeldge G, Palmaz JC, Rössle M, Slegerstetter V, Franke M, Gerok W, Wenz W, Farthman E (1990) Transjugular intrahepatic portacaval stent shunt: Preliminary clinical results. Radiology 174:1027–1030
Richter GM, Noeldge G, Palmaz JC, Roessle M (1990) The transjugular intrahepatic portosystemic stent-shunt (TIPSS): Results of a pilot study. Cardiovasc Intervent Radiol 13:200–207
Zemel G, Katzen BT, Becker GJ, Benenati JF, Salle DS (1991) Percutaneous transjugular portosystemic shunt. JAMA 266:390–393
Richter GM, Noeldge G, Roessle M, Palmaz JC (1991) Evolution and clinical introduction of TIPSS, the Transjugular Intrahepatic Portosystemic Stent-Shunt. Semin Intervent Radiol 8:331–340
Ring EJ, Lake JR, Roberts JP, Gordon RL, LaBerge JM, Read AE, Sterneck MR, Ascher NL (1992) Using transjugular intrahepatic portosystemic shunts to control variceal bleeding before liver transplantation. Ann Intern Med 116:304–309
LaBerge JM, Ferrell LD, Ring EJ, Gordon RL, Lake JR, Roberts JP, Ascher NL (1991) Histopathologic study of transjugular intrahepatic portosystemic shunts. JVIR 2:549–556
Conn HO, Leevy CM, Vlahcevic AR, Rodgers JB, Maddrey WC, Seef L, Levy LL (1977) Comparison of lactulose and nemycin in the treatment of chronic portal systemic encephalopathy. A double blind controlled trial. Gastroenterology 72:573–583
Longo JM, Bilbao JI, Rousseau H, Joffre F, Vinel JP, Garcia-Villareal L, Sangro B (1992) Transjugular intrahepatic portosystemic shunt (TIPS) guided by color-flow Doppler sonography. Radiology 184:284–290
Rösch J, Hanafee WN, Snow H (1969) Transjugular portal venography and radiologie portacaval shunt: An experimental study. Radiology 92:1112–1114
Teisseire R, Clanet J, Broussy P, Cassigneul J, Fourtanier G, Pascal JP (1979) Abord transjugulaire du système porte. Applications au diagnostic, au pronostic et à la thérapeutique des hémorragies digestives du cirrhotique. Gastroentérol Clin Biol 3:425–432
Vinel JP, Scotto JM, Levade M, Teisseire M, Cassigneul J, Calès P, Putois J, Pascal JP (1985) Embolisation des varices œsophagiennes par voie transjugulaire en urgence dans le traitement des hémorragies digestives graves du cirrhotique. Etude prospective de 84 patients. Gastroentérol Clin Biol 9:814–818
Rousseau H, Puel J, Joffre F, Siwart U, Duboucher C, Imbert C, Knight C, Kropf L (1987) Wallstent self-expanding endovascular prosthesis: An experimental study. Radiology 164:709–714
Rousseau H, Morfaux V, Joffre F, Ton That H, Goudable C, Bartoli P, Yong MY (1989) Treatment of hæmodialysis arteriovenous fistula stenosis by percutaneous implantation of new intravascular stent. J Intervent Radiol 4:161–167
Rösch J, Hanafee WN, Snow H, Barenfus M, Gray R (1971) Transjugular intrahepatic portacaval shunt: An experimental work. Am J Surg 121:588–592
Palmaz JC, Sibbitt RR, Reuter SR, Garcia F, Tio FO (1985) Expandable intrahepatic portacaval shunt stents: Early experience in dog. AJR 145:821–825
Rösch J, Uchida BT, Putnam JS, Buschman BS, Law RD, Hershey AL (1987) Experimental intrahepatic portocaval anastomosis: Use of expandable Gianturco stents. Radiology 162:481–485
Burgener FA, Gutierrez OH (1988) Experimental intrahepatic portacaval shunts created in portal hypertension by balloon angioplasty catheters. Invest Radiol 23:24–29
Colapinto RF, Stronell RD, Gildiner M, Ritchie AC, Langer B, Taylor BR, Blendis LM (1983) Formation of intrahepatic portosystemic shunts using a balloon dilatation catheter: Preliminary clinical experience. AJR 140:709–714
Galambos JT (1985) Portal hypertension. Sem Liver Dis 5:277–290
Pagliaro L, Burroughs AK, Sorensen TIA, Lebrec D, Morabito A, D'Amico G, Tinè F (1989) Therapeutic controversies and randomized controlled trials (RCTs): Prevention of bleeding and rebleeding in cirrhosis. Gastroenterol Int 2:71–84
Viallet A, Marleau D, Huet PM (1975) Hemodynamic evaluation of patients with portal hypertension: Relationship between bleeding varices and portohepatic gradient. Gastroenterology 69:1297–1300
Palmaz JC, Tio FO, Schatz RA, Alvarado R, Rees C, Garcia O (1988) Early endothelialization of balloon-expandable stents: Experimental observations. J Intervent Radiol 3:119–124
Noeldge G, Haag K, Sellinger M, Ochs A, Rössle M (1992) Treatment of portal hypertension with the transjugular intrahepatic porto-systemic shunt: Follow-up studies in 92 patients (abstract) Radiology 185 (suppl):179
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Rousseau, H., Vinel, JP., Bilbao, J.I. et al. Transjugular intrahepatic portosystemic shunts using the Wallstent prosthesis: A follow-up study. Cardiovasc Intervent Radiol 17, 7–11 (1994). https://doi.org/10.1007/BF01102064
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DOI: https://doi.org/10.1007/BF01102064