Abstract
We report on an adenoid cystic carcinoma (ACC) with a clonal deletion of 17p as the only karyotypic abnormality. Using different chromosome 17-derived probes we showed by FISH that the deletion encompassed thep53 tumour suppressor gene. Immunohistochemical analysis revealed overexpression ofp53 protein in a subpopulation of cells, suggesting a mutation in the remainingp53 allele in these cells. Our findings provide novel information about possible progressional pathways in ACC, and demonstrate the value of combining conventional cytogenetic analysis with molecular cytogenetic and immunohistochemical methods. This approach is particularly useful in cases with minor cytogenetic abnormalities at the border of visibility.
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References
Higashi K, Jin Y, Johansson M, Heim S, Mandahl N, Biörklund A, Wennerberg J, Hambraeus G, Johansson L, Mitelman F (1991) Rearrangement of 9p13 as the primary chromosomal aberration in adenoid cystic carcinoma of the respiratory tract. Genes Chromosom Cancer 3:21–23
Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991)p53 mutations in human cancers. Science 253:49–53
Hrynchak M, White V, Berean K, Horsman D (1994) Cytogenetic findings in seven lacrimal gland neoplasms. Cancer Genet Cytogenet 75:133–138
Jin Y, Mertens F, Limon J, Mandahl N, Wennerberg J, Dictor M, Heim S, Mitelman F (1994) Characteristic karyotypic features in lacrimal and salivary gland carcinomas. Br J Cancer 70:42–47
Levine AJ, Momand J, Finley CA (1991) Thep53 tumour suppressor gene. Nature 351:453–456
López-Ginés C, Cérda-Nicolás M, Llombart-Bosch A (1994) Cytogenetic findings in a new case of adenoid cystic carcinoma arising in sphenoidal sinus. Cancer Genet Cytogenet 75:150–152
Mitelman F (ed) (1991) ISCN Guidelines for cancer cytogenetics. (Supplement to an international system for human cytogenetic nomenclature) Karger, Basel
Nordkvist A, Mark J, Gustavsson H, Bang G, Stenman G (1994) Nonrandom chromosome rearrangements in adenoid cystic carcinoma of the salivary glands. Genes Chromosom Cancer 10:115–121
Sandros J, Stenman G, Mark J (1990) Cytogenetic and molecular observations in human and experimental salivary gland tumours. Cancer Genet Cytogenet 44:153–167
Stenman G, Dahlenfors R, Mark J, Sandberg N (1982) Adenoid cystic carcinoma: a third type of human salivary gland neoplasm characterized cytogenetically by reciprocal translocations. Anticancer Res 2:11–16
Tomich CE (1991) Adenoid cystic carcinoma. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, pp 333–349
Vogelstein B, Kinzler KW (1992)p53 function and dysfunction. Cell 70:523–526
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Röijer, E., Dahlenfors, R., Mark, J. et al. Observations by chromosome banding, FISH and immunohistochemistry in an adenoid cystic carcinoma with del(17)(p13) as the sole deviation. Virchows Archiv 430, 339–342 (1997). https://doi.org/10.1007/BF01092758
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DOI: https://doi.org/10.1007/BF01092758