Abstract
Retinoic acid has pronounced effects on cultures of neoplastic cells. These have attracted the attention of pathologists, but it is important to note that much of the critical data about retinoic acid has been obtained from the current extension of our knowledge in the field of development. Some of these changes are reviewed here.
Similar content being viewed by others
References
Bedo G, Santisteban P, Aranda A (1989) Retinoic acid regulates growth hormone gene expression. Nature 339:231–234
Berry CL (1992) What's in a homeobox. The development of pattern during embryonic growth (editorial). Virchows Arch [A] 420:291–294
Brickell PM, Tickle C (1989) Morphogens in chick limb development. BioEssays 11:145–149
Egawa N, Maillet B, VanDamm B, DeGreve J, Kloppel G (1996) Differentiation of pancreatic carcinoma induced by retinoic acid or sodium butyrate: a morphological and molecular analysis of four cell lines. Virchows Arch 429:59–68
Fawcett D, Pasceri P, Fraser R, Colbert M, Rossant J, Giguere V (1995) Postaxial polydactyly in forelimbs of CRABP-II mutant mice. Development 121:671–679
Gale E, Prince V, Lumsden A, Clarke J, Holder N, Maden M (1996) Late effects of retinoic acid on neural crest and aspects of rhombomere activity. Development 122:783–793
Giguere V, Ong ES, Segui P, Evans RM (1987) Identification of a receptor for the morphogen retinoic acid. Nature 330:624–629
Helms J, Thaller C, Eichele G (1994) Relationship between retinoic acid andsonic hedgehog, two polarising signals in the wing bud. Development 120:3267–3274
Lampron C, Rochette-Egly C, Gorry P, Dolle P, Mark M, Lufkin T, LeMeur M, Chambon P (1995) Mice deficient in cellular retinoic acid binding protein II (CRABPII) or both CRABPI and CRABPII are essentially normal. Development 121:539–548
Lewis J, Martin P (1989) Vertebrate development. Limbs: a pattern emerges. Nature 342:734–735
Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P (1994) Function of the retinoic acid receptors (RAR's) during development. 1. Craniofacial and skeletal abnormalities in RAR double mutants. Development 120:2723–2748
Lumsden A (1988) Diffusable factors and chemotropism in the development of the central nervous system. In: Parnavelas JG, Stern CD, Stirling RV (eds) The making of the nervous system. Oxford Science Publications, Oxford, pp 166–87
Marshall H, Nonchev S, Sham MH, Muchamore I, Lumsden A, Krumlauff R (1992) Retinoic acid alters hindbrainHox code and induces transformation of rhombomeres 2/3/into a 4/5 identity. Nature 360:737–741
Perez-Castro AV, Tran VT, Nguyen-Huu MC (1993) Defective lens fibre differentiation and pancreatic tumorigenesis caused by ectopic expression of the cellular retinoic acid-binding protein. Development 119:363–375
Petkovich M, Brand NJ, Krust A, Chambon P (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444–450
Robertson M (1987) Towards a biochemistry of morphogenesis. Nature 330:420–421
Rodriguez-Tebar A, Rohrer H (1991) Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neurons. Development 112:813–820
Rosa FW (1983) Teratogenicity of isotretinoin. Lancet II:513
Rothman KJ, Moore LL, Singer MS, Nguyen U-SDT, Mannino S, Milunsky A (1995) Teratogenicity of high vitamin A intake. N Engl J Med 333:1369–1373
Ruberte E, Friedrich V, Morriss-Kay G, Chanbon P (1992) Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Development 115: 973–987
Thaller C, Eichele G (1987) Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327:625–628
Thaller C, Eichele G (1990) Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud. Nature 345:815–819
Vincent TS, Gian G Re, Hazen-Martin DJ, Tarnowski BI, Willingham MC, Garvin AJ (1996) All-trans-retinoic acid-induced growth suppresion of blastemal Wilms' tumour. Pediatr Pathol Lab Med 16:777–789
Wagner M, Thaller C, Jessell T, Eichele G (1990) Polarising activity and retinoid synthesis in the floor plate of the neural tube. Nature 345:819–822
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Berry, C. Retinoic acid, neoplasia, differentiation and development. Virchows Archiv 430, 267–270 (1997). https://doi.org/10.1007/BF01092748
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01092748