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Membrane phospholipids and adrenergic receptor function

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Abstract

We have reviewed the effects on adrenergic receptors by membrane phospholipid alterations secondary to oxidative stress and phospholipases' activity. Experimental evidences indicate that the function of both α- and β-adrenoceptors is regulated by their phospholipid microdomain; however, the underlying mechanism is still undefined. No information seems to be available on the influence of phospholipids on β2-adrenoceptors and on all adrenoceptors' subtypes. Thus, further studies are necessary to clarify the role of membrane phospholipids in regulating the function of each member of the adrenergic receptor superfamily.

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References

  1. Strosberg AD: Structure, function and regulation of adrenergic receptors. Protein Sci 2: 1198–1209, 1993

    PubMed  Google Scholar 

  2. Ahlquist RP: A study of adrenotropic receptors. Am J Physiol 153: 586–600, 1948

    Google Scholar 

  3. Bylun DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowtiz RJ, Minneman K, Molinoff PB, Ruffolo RR, Trendelenburg V: International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol Rev 46: 121–136, 1994

    PubMed  Google Scholar 

  4. Ford APDW, Williams TJ, Blue DR, Clarke DE: 221-1 classification: Sharpening Occam's razor. Trends Pharmacol Sci 15: 167–170, 1994

    PubMed  Google Scholar 

  5. Ruffolo RR, Hieble PB: α-Adrenoceptors. Pharmac Ther 61: 1–64, 1994

    Google Scholar 

  6. Exton JH. Phosphoinositide phospholipases and G proteins in hormone action. Annu Rev Physiol 56: 349–369, 1994

    PubMed  Google Scholar 

  7. Berridge M: Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 220: 345–360, 1984

    PubMed  Google Scholar 

  8. Tang W-J, Gilman AG: Adenylyl cyclases. Cell 70: 869–872, 1992

    PubMed  Google Scholar 

  9. Birnbaumer L: G proteins in signal transduction. Annu Rev Pharmacol Toxicol 30: 675–705, 1990

    PubMed  Google Scholar 

  10. Clapham DE, Neer EJ: New roles for G-proteins βγ-dimers in transmembrane signalling. Nature 365: 403–406, 1993

    PubMed  Google Scholar 

  11. Sternweis PC: The active role of βγ in signal transduction. Curr Opin Cell Biol 6: 198–203, 1994

    PubMed  Google Scholar 

  12. Kinsella BT, O'Mahoney DJ: Lipid modification of G proteins. Trends Cardiovasc Med 4: 27–34, 1994

    Google Scholar 

  13. Bernstein G, Blank JL, Jhon D-Y, Exton JH, Rhee SG, Ross EM: Phospholipase C-β2 is a GTPase activating protein for Gq/11, its physiological regulator. Cell 70: 411–418, 1992

    PubMed  Google Scholar 

  14. Brown AM: Membrane-delimited cell signalling complexes: direct ion channel regulation by G proteins. J Membr Biol 131: 93–104, 1993

    PubMed  Google Scholar 

  15. Wu D, Simon MI: Identification of critical regions on phospholipase C-β required for activation by G-proteins. J Biol Chem 268: 3704–3709, 1993

    PubMed  Google Scholar 

  16. Carruthers A, Melchior DL: Effect of lipid environment on membrane transport: the human erythrocyte sugar transport protein/bilayer system. Annu Rev Physiol 50: 257–271, 1988

    PubMed  Google Scholar 

  17. Halliwell B: Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 91(suppl 3C): 14S-22S, 1991

    Google Scholar 

  18. Kaul N, Siveski-Iliskovic N, Hill M, Slezak J, Singal PK: Free radicals and the heart. J Pharmacol Toxicol Methods 30: 55–67, 1993

    PubMed  Google Scholar 

  19. Sies H, Cadenas E: Oxidative stress: damage to intact cells and organs. Phil Trans Roy Soc London B 311: 617–631, 1985

    PubMed  Google Scholar 

  20. Freeman BA, Crapo JD: Biology of disease. Free radicals and tissue injury. Lab Invest 47: 412–426, 1982

    PubMed  Google Scholar 

  21. Wolff SP, Garner A, Dean RT: Free radicals, lipids and protein degradation. Trends Biochem Sci 11: 27–31, 1986

    Google Scholar 

  22. Haenen GR, Veerman M, Bast A: Reduction of β-adrenoceptor function by oxidative stress in the heart. Free Radical Biol Med 9: 279–288, 1990

    Google Scholar 

  23. McMurchie EJ: Dietary lipids and the regulation of membrane fluidity and function. In: R.C. Aloia, C.C. Curtain, L.M. Gordon (eds). Physiological regulation of membrane fluidity. Alan R. Liss, New York, 1988, pp 189–237

    Google Scholar 

  24. Shinitzky M: Membrane fluidity and cellular functions. In: M. Shinitzky (ed.). Physiology of membrane fluidity, vol. 1. CRC Press, Boca Raton, 1984, pp 1–51

    Google Scholar 

  25. Richter C: Biophysical consequences of lipid peroxidation in membrane. Chem Phys Lipids 44: 175–189, 1987

    PubMed  Google Scholar 

  26. Hershkowitz M, Heron D, Samuel D, Shinitzky M: Modulation of protein phosphorylation and receptor binding in brain membranes by changes in lipid microviscosity: implication for aging. Prog Brain Res 56: 419–425, 1982

    PubMed  Google Scholar 

  27. Kaneko M, Panagia V, Paolillo G, Majumder S, Ou C, Dhalla NS: Inhibition of cardiac phosphatidylethanolamine N-methylation by oxygen free-radicals. Biochim Biophys Acta 1021: 33–38, 1990

    PubMed  Google Scholar 

  28. Meij JTA, Suzuki S, Panagia V, Dhala NS: Oxidative stress modifies the activity of cardiac sarcolemmal phospholipase C. Biochim Biophys Acta 1199: 6–12, 1994

    PubMed  Google Scholar 

  29. Dai J, Meij JTA, Padua R, Panagia V: Depression of sarcolemmal phospholipase D activity by oxidant-induced thiol modification. Circ Res 71: 970–977, 1992

    PubMed  Google Scholar 

  30. Limas CJ: Effect of phospholipid methylation on β-adrenergic receptors in the normal and hypertrophied rat myocardium. Circ Res 47: 536–541, 1980

    PubMed  Google Scholar 

  31. Okumura K, Ogawa K, Sataka T: Phospholipid methylation in canine membranes: relations to β-adrenergic receptors and digitalis receptors. Jpn Heart J 24: 215–225, 1983

    PubMed  Google Scholar 

  32. Strittmatter WJ, Hirata F, Axelrod J: Phospholipid methylation unmasks cryptic β-adrenergic receptors in rat reticulocytes. Science 204: 1205–1207, 1979

    PubMed  Google Scholar 

  33. Hirata F: Regulation of membrane fluidity by phospholipid methylation. In: R.C. Aloia, J.M. Boggs (eds.). Membrane fluidity in biology. Academic Press, Orlando, 1985, pp 247–257

    Google Scholar 

  34. Pruijn FB, Van Gelderen H, Bast A: The effects of radical stress and N-ethylmaleimide on rat hepatic α1-adrenergic receptors. Toxicol Lett 45: 73–82, 1989

    PubMed  Google Scholar 

  35. Vetter R, Dai J, Mesaeli N, Panagia V, Dhalla NS: Role of sulfhydryl groups in phospholipid methylation reactions of cardiac sarcolemma. Mol Cell Biochem 103: 85–96, 1991

    PubMed  Google Scholar 

  36. Van der Vliet A, Bast A: Effect of oxidative stress on recepotors and signal transmission. Chem-Biol Interactions 85: 95–116, 1992

    Google Scholar 

  37. Waite M: The phospholipases. Handbook of lipid research, vol. 5, Plenum Press, New York, 1988, pp 332

    Google Scholar 

  38. Axelrod J: Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction. Biochem Soc Trans 18: 503–507, 1990

    PubMed  Google Scholar 

  39. Exton JH: Phosphoinositide phospholipases and G protein in hormone action. Annu Rev Physiol 56: 349–369, 1994

    PubMed  Google Scholar 

  40. Billah MM, Anthes JC: The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J 269: 281–291, 1990

    PubMed  Google Scholar 

  41. Prasad MR, Popescu LM, Moraru II, Liu X, Maity S, Engelman RM, Das DK. Role of phospholipase A2 and C in myocardial ischemic reperfusion. Am J Physiol 260: H877-H883, 1991

    PubMed  Google Scholar 

  42. Panagia V, Meij JTA, Mesaeli N, Singal RK, Dhalla NS: Depression of sarcolemmal phospholipase C activity in congestive heart failure. In: N.S. Dhalla, G.N. Pierce, V. Panagia, R.E. Beamish (eds.) Heart hypertrophy and failure. Kluwer Acad. Publ, Boston, in press

  43. Dai J, Panagia V: Distinct changes of sarcolemmal and sarcoplasmic reticular phospholipase D activity in ischemic-reperfused heart. FASEB J 7: A121, 1993

    Google Scholar 

  44. Kirilovsky J, Schramm M: Delipidation of a β-adrenergic receptor preparation and reconstitution by specific lipids. J Biol Chem 258: 6841–6849, 1983

    PubMed  Google Scholar 

  45. Limbird LE, Lefkowitz RJ: Adenylate cyclase-coupled beta-adrenergic receptors: Effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. Mol Pharmacol 12: 559–567, 1976

    PubMed  Google Scholar 

  46. Shreeve SM, Valliere JE: The α1-adrenoceptor is inactivated by alterations in membrane phosphilipids. Eur J Pharmacol 226: 29–33, 1992

    PubMed  Google Scholar 

  47. Skúladóttir GV, Schiöth HB, Gudbjarmason S: Polyunsaturated fatty acids in heart muscle and α1-adrenoceptor binding properties. Biochim Biophys Acta 1178: 49–54, 1993

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Taché Avenue, R2H 2A6, Winnipeg, Manitoba, Canada

    Sean Williams, Johanna T. A. Meij & Vincenzo Panagia

  2. Departments of Physiology and Anatomy, Faculty of Medicine, University of Manitoba, R2H 2A6, Winnipeg, Manitoba, Canada

    Sean Williams, Johanna T. A. Meij & Vincenzo Panagia

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  2. Johanna T. A. Meij
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  3. Vincenzo Panagia
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Williams, S., Meij, J.T.A. & Panagia, V. Membrane phospholipids and adrenergic receptor function. Mol Cell Biochem 149, 217–222 (1995). https://doi.org/10.1007/BF01076580

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