Skip to main content
Log in

Near-death experiences: A neurophysiologic explanatory model

  • Published:
Journal of Near-Death Studies

Abstract

Prior hypotheses as to the etiology of near-death experiences (NDEs) have been limited to psychiatric explanations or brief discussions of endorphins as causative agents. We present a neurophysiological explanation for NDEs based on their similarities with lysergic acid-, ketamine-, and hypercapnia-induced hallucinations. We believe the core NDE is genetically imprinted and triggered by serotonergic mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Cahal, D.A. (1957). Effects of nalorphine on the behavior of healthy human volunteers.Journal of Mental Sciences, 103, 850–855.

    Google Scholar 

  • Carr, D. (1982). Pathophysiology of stress-induced limbic lobe dysfunction: A hypothesis for NDEs.Anabiosis: The Journal of Near-Death Studies, 2, 75–90.

    Google Scholar 

  • Collier, B. (1972). Ketamine and the conscious mind.Anesthesia, 27, 120–134.

    Google Scholar 

  • Comer, N.L., Madow, L., & Dixon, J. (1967). Observations of sensory deprivation in a life threatening situation.American Journal of Psychiatry, 124, 164–167.

    PubMed  Google Scholar 

  • Domino, E.F., Chodoff, P., & Corssen, G. (1965). Human pharmacology of CI-581, a new intravenous agent chemically linked to phencyclidine.Federation Proceedings, 24, 268.

    Google Scholar 

  • Ehrenwald, J. (1974). Out of body experiences and the denial of death.Journal of Nervous and Mental Disease, 159, 227–233.

    PubMed  Google Scholar 

  • Gabbard, G.O., & Twemlow, S.W. (1983).With the Eyes of the Mind. New York: Praeger.

    Google Scholar 

  • Green, J.T., & Friedman, P. (1983). Near-death experiences in a Southern California population.Anabiosis:The Journal of Near-Death Studies, 3, 77–96.

    Google Scholar 

  • Greyson, B. (1983). The psychodynamics of near-death experiences.Journal of nervous and Mental Disease, 6, 376–381.

    Google Scholar 

  • Greyson, B., & Stevenson, I. (1980). The phenomenology of near-death experiences.American Journal of Psychiatry, 137, 1193–1196.

    PubMed  Google Scholar 

  • Grof, S., & Halifax, J. (1977).The Human Encounter With Death. New York: E.P. Dutton.

    Google Scholar 

  • Judson, I.R., & Wiltshaw, E. (1983). A near-death experience.Lancet, 2, 561–562.

    PubMed  Google Scholar 

  • Meduna, L.T. (1950).Carbon Dioxide Therapy: A Neurophysiological Treatment of Nervous Disorders. Springfield, IL: Charles C. Thomas.

    Google Scholar 

  • Moody, R.A., Jr. (1975).Life After Life. Covington, GA: Mockingbird.

    Google Scholar 

  • Morse, M., Castillo, P., Venecia, D., Milstein, J., & Tyler, D.C. (1986). Childhood near-death experiences.American Journal of Diseases of Children 140, 1110–1114.

    PubMed  Google Scholar 

  • Morse, M.L., Connor, D., & Tyler, D. (1985). Near-Death experiences in a pediatric population.American Journal of Diseases of Children, 139, 595–600.

    PubMed  Google Scholar 

  • Noyes, R. (1979). Near-death experiences: Their interpretation and significance. In Kastenbaum, R. (Ed.),Between Life and Death (pp. 73–88). New York: Springer.

    Google Scholar 

  • Penfield, W. (1955). The role of the temporal cortex in certain psychical phenomena.Journal of Mental Science, 101, 451–465.

    PubMed  Google Scholar 

  • Penfield, W. (1975).The Mystery of the Mind. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Penfield, W., & Rasmussen, T. (1950).The Cerebral Cortex of Man: A Clinical Localization of Function. New York: Macmillan.

    Google Scholar 

  • Ring, K. (1980).Life at Death: A Scientific Investigation of the Near-Death Experience. New York: Coward, McCann & Geoghegan.

    Google Scholar 

  • Rogo, D.S. (1984). Ketamine and the near-death experience.Anabiosis: The Journal of Near-Death Studies, 4, 87–96.

    Google Scholar 

  • Sabom, M. (1982).Recollections of Death: A Medical Investigation. New York: Harper and Row.

    Google Scholar 

  • Snow, A.E., Tucker, S.M., & Dewey, W.L. (1982). The role of neurotransmitters in stress induced antinociception.Pharmacology Biochemistry and Behavior, 16, 47–50.

    Google Scholar 

  • Strahlendorf, J.C.R., Goldstein, F.J., Rossi, G.V., & Malseed, R.T. (1982). Differential effects of LSD, serotonin, and L-tryptophan on visually evoked responses.Pharmacology Biochemistry and Behavior, 16, 51–55.

    Google Scholar 

  • White, F., & Appel, T. (1982). Lysergic acid diethylamide and lisuride: Differentiation of their neuropharmacological actions.Science, 216, 535–536.

    PubMed  Google Scholar 

  • Winson, J. (1986).Brain and Psyche. New York: Random House.

    Google Scholar 

  • Winson, J., & Abzug, C. (1977). Gating of neuronal transmission in the hippocampus.Science, 196, 1223–1225.

    PubMed  Google Scholar 

  • Winson, J., & Abzug, C. (1978). Neuronal transmission through hippocampal pathways dependent on behavior.Journal of Neurophysiology, 417, 716–722.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morse, M.L., Venecia, D. & Milstein, J. Near-death experiences: A neurophysiologic explanatory model. J Near-Death Stud 8, 45–53 (1989). https://doi.org/10.1007/BF01076138

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01076138

Keywords

Navigation