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Allopurinol-induced granulomatous hepatitis

  • Case Report
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Summary

A 55-year-old female developed myalgias, arthralgias, fever, and abnormal liver function four weeks following intake of allopurinol. Granulomas were found in the liver. Withdrawal of allopurinol resulted in gradual improvement of clinical, biochemical, and histological lesions in this patient. To our knowledge, this is the second case report of granulomatous hepatitis following intake of allopurinol.

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, Mount Sinai Medical Center of Miami Beach, 4300 Alton Road, 33140, Miami, Florida

    Carmelita R. Espiritu MD, Jaime Alalu MD & Lewis G. Glueckauf MD

  2. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center of Miami Beach, 4300 Alton Road, 33140, Miami, Florida

    Jack Lubin MD

  3. the University of Miami School of Medicine, 4300 Alton Road, 33140, Miami, Florida

    Jack Lubin MD

Authors
  1. Carmelita R. Espiritu MD
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  2. Jaime Alalu MD
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  3. Lewis G. Glueckauf MD
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  4. Jack Lubin MD
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Espiritu, C.R., Alalu, J., Glueckauf, L.G. et al. Allopurinol-induced granulomatous hepatitis. Digest Dis Sci 21, 804–806 (1976). https://doi.org/10.1007/BF01073035

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  • DOI: https://doi.org/10.1007/BF01073035

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