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Acute pancreatitis following renal allotransplantation

A lethal complication

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Abstract

Since first described by Starzl in 1964 (1), acute pancreatitis following renal homotransplantation has been the subject of sporadic reports and reviews (2–5). The generally reported incidence has been around 2%, with a mortality rate of 50–60%. A recent experience with such a patient caused us to retrospectively analyze our own series of renal transplant recipients. In an eight-year period, there were six patients who had documented pancreatitis out of a total 120 renal homograft recipients, an incidence of 5%. The mortality was distressingly high; five out of the six succumbed directly to this complication, a rate of 83%. The purpose of this paper is to review these six patients in detail, with special attention to the protean etiologies and manifestations of this lethal complication.

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References

  1. Starzl TE: Experience in Renal Transplantation. Philadelphia, WB Saunders, 1964, p 117

    Google Scholar 

  2. Johnson WC, Nabseth DC: Pancreatitis in renal transplantation. Ann Surg 171:309, 1970

    Google Scholar 

  3. Penn I, Durst AL, Machado M, Halgrinson CG, Booth AS, Pulman CW, Groth CG, Starzl TE: Acute pancreatitis and hyperamylasemia in renal homograft recipients. Arch Surg 105:167, 1972

    Google Scholar 

  4. Renning JA, Warden GD, Stevens LF, Reemtsma K: Pancreatitis after renal transplantation. Am J Surg 123:293, 1972

    Google Scholar 

  5. Corrodi P, Knoblauch M, Binswanger W, Scholzel E, Largiader F: Pancreatitis after renal transplantation. Gut 16:285, 1975

    Google Scholar 

  6. Penn L, Groth CG, Brettschneider L, Martin AJ, Marchioro TL, Starzl TE: Surgically correctable intraabdominal complications before and after renal homotransplantation. Ann Surg 168:865, 1968

    Google Scholar 

  7. Furkelstein FO, Black HR: Risk factor analysis in renal transplantation. Am J Med Sci 267:159, 1974

    Google Scholar 

  8. Baker RJ: Acute surgical diseases of the pancreas. Surg Clin North Am 52:259, 1972

    Google Scholar 

  9. Carey LC: Acute and chronic pancreatitis. Surg Clin North Am 55:325, 1975

    Google Scholar 

  10. Gliedman MC, Bolooki H, Rosen RG: Acute pancreatitis. Curr Probl Surg, August 1970

  11. Aldrete JS: Gastrointestinal and hepatic complications affecting patients with renal allografts. Am J Surg 129:115, 1975

    Google Scholar 

  12. Woods JE, Anderson CF, Frohnert PP, Petrie CR: Pancreatitis in renal allografted patients. Mayo Clin Proc 47:193, 1972

    Google Scholar 

  13. Julien PJ, Goldberg HI, Margulis AR, Belzer FO: Gastrointestinal complications following renal transplantation. Radiology 117:37, 1975

    Google Scholar 

  14. Owens ML, Wilson SE, Saltzman R, Gordon HE: Gastrointestinal complications after renal transplantation. Arch Surg 111:467, 1976

    Google Scholar 

  15. Frey CF: The operative treatment of pancreatitis. Arch Surg 98:406, 1969

    Google Scholar 

  16. Carone FA, Liebow AA: Acute pancreatic lesions in patients treated with ACTH and adrenal corticoids. N Engl J Med 257:690, 1957

    Google Scholar 

  17. Nelp WB: Acute pancreatitis associated with steroid therapy. Arch Intern Med 108:102, 1961

    Google Scholar 

  18. Schrier RW, Bedger RJ: Steroid induced pancreatitis. JAMA 194:176, 1965

    Google Scholar 

  19. Dujovie CA, Azarnoff DL: Clinical complications of corticosteroid therapy. Med Clin North Am 57:1331, 1973

    Google Scholar 

  20. Kawanishi H, Rudolph E, Bull FE: Azathioprine-induced acute pancreatitis. N Engl J Med 289:357, 1973

    Google Scholar 

  21. Nogueira JR, Freedman MA: Acute pancreatitis as a complication of Imuran therapy in regional enteritis. Gastroenterology 62:1040, 1972

    Google Scholar 

  22. Turchi JJ, Flandreau RH, Forte AL, French GN, Ludwig GD: Hyperparathyroidism and pancreatitis. JAMA 180:799, 1962

    Google Scholar 

  23. Cameron JL, Crisler C, Margolis S, DeMeester RT, Zuidema G: Acute pancreatitis with hyperlipemia. Surgery 70:53, 1971

    Google Scholar 

  24. Tilney NL, Collins JJ, Wilson RE: Hemorrhagic pancreatitis: A fatal complication of renal transplantation. N Engl J Med 274:1054, 1966

    Google Scholar 

  25. Bergan JJ: ACS/NIH Organ Transplant Registry Newsletter (No. 14), 4:1976

    Google Scholar 

  26. Hayes MF, Rosenbaum RW, Zibelman M, Matsumoto T: Adult respiratory distress syndrome in association with acute pancreatitis. Am J Surg 127:314, 1974

    Google Scholar 

  27. Warshaw AL: Pathogenesis of pulmonary edema in acute pancreatitis. Ann Surg 182:505, 1975

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University Hospital University of California Medical Center, San Diego, 225 West Dickinson Street, 92103, San Diego, California

    Peter M. Taft MD, Amy C. Jones RN, Geoffrey M. Collins MD &  Nicholas A. Halasz MD

Authors
  1. Peter M. Taft MD
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  2. Amy C. Jones RN
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  3. Geoffrey M. Collins MD
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  4. Nicholas A. Halasz MD
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Taft, P.M., Jones, A.C., Collins, G.M. et al. Acute pancreatitis following renal allotransplantation. Digest Dis Sci 23, 541–544 (1978). https://doi.org/10.1007/BF01072698

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