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Selectivity of small intestinal exudate in celiac disease and Crohn's disease

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Abstract

The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were relatively nonselective. It is believed that this loss of selectivity is secondary to basement membrane damage. An analogy is drawn with the renal lesion in nephrotic syndrome where basement membrane damage is associated with nonselective proteinuria.

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Authors and Affiliations

  1. Department of Gastroenterology, Royal Victoria Hospital, BH1 4JG, Bournemouth

    J. G. C. Kingham MD, MRCP & C. A. Loehry MD, MRCP

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  1. J. G. C. Kingham MD, MRCP
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  2. C. A. Loehry MD, MRCP
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Kingham, J.G.C., Loehry, C.A. Selectivity of small intestinal exudate in celiac disease and Crohn's disease. Digest Dis Sci 23, 33–38 (1978). https://doi.org/10.1007/BF01072572

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  • DOI: https://doi.org/10.1007/BF01072572

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