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Basophilic leukemia presenting as gastroduodenal ulceration

Effect of H-2-receptor blockade

  • Case Report
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Summary

A patient with multiple gastroduodenal ulcers and gastric hypersecretion due to histamine excess associated with basophilic leukemia is described. Treatment with the histamine H-2-receptor blocker, cimetidine, was able to abolish the gastric hypersecretion and gastrointestinal blood loss. A literature review produced four other cases of multiple gastroduodenal ulceration with this disease, suggesting that it is more common than previously recognized. The availability of a potent H-2-receptor antagonist offers effective and specifically tailored therapy to counteract the gastrointestinal effects of hyperhistaminemia in basophilic leukemia and other “histamine excess” diseases.

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Authors and Affiliations

  1. Department of Medicine, Medical Colloge of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia

    Robert W. Swisher MD, John M. Mueller MD &  L. Gregg Halloran MD

  2. Department of Surgery, Medical Colloge of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia

    Robert W. Swisher MD, John M. Mueller MD &  L. Gregg Halloran MD

Authors
  1. Robert W. Swisher MD
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  2. John M. Mueller MD
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  3. L. Gregg Halloran MD
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Swisher, R.W., Mueller, J.M. & Halloran, L.G. Basophilic leukemia presenting as gastroduodenal ulceration. Digest Dis Sci 23, 952–955 (1978). https://doi.org/10.1007/BF01072474

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  • DOI: https://doi.org/10.1007/BF01072474

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