Summary
A patient with exocrine pancreatic insufficiency and hypoalbuminemic edema was shown also to have a protein-losing gastropathy secondary to giant hypertrophic gastritis (Ménétrier's disease). Despite continuation of excessive gastric protein loss, the manifestations of hypoproteinemia were reversed by oral pancreatic enzyme replacement therapy. We speculate that impaired intraluminal proteolysis exaggerated the consequences of gastric protein loss.
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This investigation was supported in part by Contract CM-43796 from the National Cancer Istitute and by Research Grant RR-585 from the National Institutes of Health, Public Health Service.
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Regan, P.T., Phillips, S.F. & Dimagno, E.P. Pancreatic insufficiency and Ménétrier's disease. Digest Dis Sci 23, 759–762 (1978). https://doi.org/10.1007/BF01072367
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DOI: https://doi.org/10.1007/BF01072367