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The role of the mucosal barrier in drug-induced gastric ulceration and erosions

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References

  1. Kirsner JB: Acid-peptic disease. In Textbook of Medicine 13th Edition. PB Beeson, W McDermott (eds.), Philadelphia, Saunders, 1971, p 1267

    Google Scholar 

  2. Skoryna SC (ed). Pathophysiology of Peptic Ulcer. Montreal, McGill University Press, 1963, pp 213–322

    Google Scholar 

  3. Segal HL: Ulcerogenic drugs and technics. Am J Med 29:780–792, 1960

    Google Scholar 

  4. Kirsner JB: Drug-induced peptic ulcer. Ann Int Med 47:666–699, 1957

    Google Scholar 

  5. Nicoloff DM: Indomethacin. Arch Surg 97:809–815, 1968

    Google Scholar 

  6. Robert A: The pro-ulcer effect of nicotine: An experimental study in the rat (abst). J Lab Clin Med 78:831, 1971

    Google Scholar 

  7. Williams AW: Effect of alcohol on gastric mucosa. Br Med J 1:256–259, 1969

    Google Scholar 

  8. Cooke AR: Drugs and peptic ulceration. Gastrointestinal Disease. MH Sleisenger, JS Fordtran (eds). Philadelphia, Saunders, 1973, pp 642–656

    Google Scholar 

  9. Langman MJS: Aspirin and the stomach. Controversy in Internal Medicine, FJ Ingelfinger et al, (eds). Philadelphian Saunders, 1974, pp 493–499

    Google Scholar 

  10. Cooke AR: Aspirin, ethanol and the stomach. Austr Ann Med 19:269–275, 1970

    Google Scholar 

  11. Langman MJS: Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding. Gut 11:627–634, 1970

    Google Scholar 

  12. Cooke AR: Corticosteroids and peptic ulcer: Is there a relationship. Am J Dig Dis 12:323–329, 1967

    Google Scholar 

  13. Friedman GD, Siegelaub AB, Seltzer CC: Cigarettes, alcohol, coffee and peptic ulcer. N. Engl J Med 290:469–473, 1974

    Google Scholar 

  14. Astley CE: Gastritis, aspirin and alcohol (letter). Br Med J 4:484, 1967

    Google Scholar 

  15. Brown RK, Mitchell N: The influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer. Gastroenterology 31:198–203, 1956

    Google Scholar 

  16. Jennings GH: Causal influences in haematemesis and melaena. Gut 6:1–13, 1965

    Google Scholar 

  17. Needham CD, Kyle J, Jones PF, Johnston SJ, Kerridge DF: Aspirin and alcohol in gastrointestinal haemorrhage. Gut 12:819–921, 1971

    Google Scholar 

  18. Allibone A, Flint FJ: Gastrointestinal haemorrhage and salicylates (letter) Lancet 2:1121, 1958

    Google Scholar 

  19. Sun DCH, Roth SH, Mitchell CS, Englund DW: Uppergastrointestinal disease in rheumatoid arthritis. Am J Dig Dis 19:405–410, 1974

    Google Scholar 

  20. Barnett CW: Tobacco smoking as a factor in the production of peptic ulcer and gastric neurosis. Boston Med Surg J 197:457–459, 1927

    Google Scholar 

  21. Trowell OA: The relation of tobacco smoking to the incidence of chronic duodenal ulcer. Lancet 1:808–809, 1934

    Google Scholar 

  22. Monson RR: Cigarette smoking and body form in peptic ulcer. Gastroenterology 58:337–344, 1970

    Google Scholar 

  23. Doll R, Jones FA, Pygott F: Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet 1:657–662, 1958

    Google Scholar 

  24. Kasanen A, Forsstroem J: Social stress and living habits in the etiology of peptic ulcer. Ann Med Intern Fenn 55:13–22, 1966

    Google Scholar 

  25. Edwards F, McKeown T, Whitefield AGW: Association between smoking and disease in men over sixty. Lancet 1:196–200, 1959

    Google Scholar 

  26. Doll R, Hill AB: Mortality in relation to smoking: 10 years' observation of British doctors. Br Med J 1:1399–1410, 1460–1467, 1964

    Google Scholar 

  27. Kahn HA: The Dorn study of smoking and mortality among US Veterans: Reports on eight and one-half years of observation. Epidemiological Approaches to the Study of Cancer and Other Diseases. National Cancer Institute Manograph No. 19. W Haenszel (ed). Bethesda, USPHS, 1966, pp 1–125

    Google Scholar 

  28. Hammond EC: Smoking in relation to the death rates of one million men and women. Epidemiological Approaches to the Study of Cancer and Other Diseases. National Cancer Institute Manograph No 19. W Haenszel (ed). Bethesda, USPHS, 1966, pp 127–204

    Google Scholar 

  29. Gillies M, Skyring A: Gastric ulcer, duodenal ulcer and gastric carcinoma: A case-control study of certain social and environmental factors. Med J Austr 2:1132–1136, 1968

    Google Scholar 

  30. Gillies M, Skyring A: Gastric and duodenal ulcer. The association between aspirin ingestion, smoking and family history of ulcer. Med J Austr 2:280–28t, 1969

    Google Scholar 

  31. Garb AE, Soule EH, Bartholomew LG, Cain JC: Steroid-induced gastric ulcer. Arch Int Med 116:899–906, 1965

    Google Scholar 

  32. Cushman P: Glucocorticoids and the gastrointestinal tract: Current status. Gut 11:534–539, 1970

    Google Scholar 

  33. Blitzer BL, Conn HO: A controlled comparison of peptic ulcer in steroid and non-steroid treated patients: An armchair investigation (Abstract). Gastroenterology 64:702, 1973

    Google Scholar 

  34. Douglas RA, Johnston ED: Aspirin and chronic gastric ulcer. Med J Austr 2:893–897, 1961

    Google Scholar 

  35. Duggan JM, Chapman BL: The incidence of aspirin ingestion in patients with peptic ulcer. Med J Austr 1:797–800, 1970

    Google Scholar 

  36. Levy M: Aspirin use in patients with major upper gastrointestinal bleeding and peptic ulcer disease. N Engl J Med 290:1158–1162, 1974

    Google Scholar 

  37. MacDonald WC: Correlation of mucosal histology and aspirin intake in chronic gastric ulcer. Gastroenterology 65:381–389, 1973

    Google Scholar 

  38. Cooke AR: The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage. Am J Dig Dis 18:225–237, 1973

    Google Scholar 

  39. Parry DJ, Wood PHN: Relationship between aspirin taking and gastroduodenal haemorrhage. Gut 303-307, 1967

  40. Muir A, Cossar IA: Aspirin and gastric haemorrhage. Lancet 1:539–541, 1959

    Google Scholar 

  41. Allibone A, Flint FJ: Bronchitis, aspirin, smoking and other factors in the aetiology of peptic ulcer. Lancet 2:179–182, 1958

    Google Scholar 

  42. Muir A, Cossar IA: Aspirin and ulcer. Br Med J 2:7–12, 1955

    Google Scholar 

  43. Alvarez AS, Summerskill WHJ: Gastrointestinal haemorrhage and salicylates. Lancet 2:920–925, 1958

    Google Scholar 

  44. Kelly JJ: Salicylate ingestion: A frequent cause of gastric hemorrhage. Am J Med Sci 232:119–128, 1956

    Google Scholar 

  45. Lange HF: Salicylates and gastric haemorrhage I. Occult bleeding II. Manifest bleeding. Gastroenterology 33:778–788, 1957

    Google Scholar 

  46. Schiller KFR, Truelove SC, Williams DG: Haematemesis and melaena with special reference to factors influencing the outcome. Br Med J 2:7–14, 1970

    Google Scholar 

  47. Muir A, Cossar IA: Aspirin and gastric bleeding: Further studies of calcium aspirin. Am J Dig Dis 6:1115–1125, 1961

    Google Scholar 

  48. Croft DN, Wood PHN: Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin. Br Med J 1:137–141, 1967

    Google Scholar 

  49. Matsumoto KK, Grossman MI: Quantitative measurement of gastrointestinal blood loss during ingestion of aspirin. Proc Soc Exp Biol Med 102:517–519, 1959

    Google Scholar 

  50. Skyring A, Bhanthumnavin K: Gastrointestinal bleeding: A comparison of mefenamic acid and aspirin. Med J Austr 1:601–603, 1967

    Google Scholar 

  51. Goulston K, Skyring A: Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleeding, Gut 5:463–466, 1964

    Google Scholar 

  52. Cotton PB, Rosenberg MT, Waldram RPL, Axon ATR: Early endoscopy of oesophagus, stomach and duodenal bulb in patients with haematemesis and melaena. Br Med J 2:505–509, 1973

    Google Scholar 

  53. Cooke AR: Do duodenal ulcers re-bleed—The importance of finding the bleeding site. Gastroenterology 65:986–987, 1973

    Google Scholar 

  54. Cooke AR, Goulston K: Failure of intravenous aspirin to increase gastrointestinal blood loss. Br Med J 3:330–332, 1969

    Google Scholar 

  55. Weiss HJ, Aledort LM, Kochwa S: The effect of salicylates on the hemostatic properties of platelets in man. J Clin Invest 47:2169–2180, 1968

    Google Scholar 

  56. Weiss HJ: Aspirin—A dangerous drug? JAMA 229:1221–1222, 1974

    Google Scholar 

  57. Leonards JR, Levy G: Aspirin induced occult gastrointestinal blood loss: Local vs systemic effects. J Pharm Sci 59:1511–1513, 1970

    Google Scholar 

  58. Grossman MI, Matsumoto KK, Lichter RJ: Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterology 40:383–388, 1961

    Google Scholar 

  59. Scheffé H: A method of judging all contrasts in the analysis of variance. Biometrika 40:87–104, 1953

    Google Scholar 

  60. Roth JA, Ivy AC: The effect of caffeine upon gastric secretion in the dog, cat and man. Am J Physiol 141:454–461, 1944

    Google Scholar 

  61. Chvasta TE, Cooke AR: Emptying and absorption of caffeine from the human stomach. Gastroenterology 61:838–843, 1971

    Google Scholar 

  62. Cooke AR, Chvasta TE, Granner DK: Histamine, pentagastrin, methyl xanthines and adenyl cyclase activity in acid secretion. Proc Soc Exp Biol Med 146:674–678, 1974

    Google Scholar 

  63. Strickland RG, Fisher JM, Taylor KB: Effect of prednisolone on gastric function and structure in man. Gastroenterology 56:675–686, 1969

    Google Scholar 

  64. Cooke AR: The role of adrenocortical steroids in the regulation of gastric secretion. Gastroenterology 52:272–281, 1967

    Google Scholar 

  65. Winship DH, Bernhard GC: Basal and histamine-stimulated human gastric acid secretion: Lack of effect of indomethacin in therapeutic doses. Gastroenterology 58:762–765, 1970

    Google Scholar 

  66. Davenport HW: Salicylate damage to the gastric mucosal barrier. N Engl J Med 276:1307–1312, 1967

    Google Scholar 

  67. Cooke AR: The simultaneous emptying and absorption of ethanol from the human stomach. Am J Dig Dis 15:449–454, 1970

    Google Scholar 

  68. Cooke AR: Ethanol and gastric function. Gastroenterology 62:501–502, 1972

    Google Scholar 

  69. Bennett JR: Smoking and the gastrointestinal tract. Gut 13:658–665, 1972

    Google Scholar 

  70. Solomon TE, Jacobson ED: Cigarette smoking and duodenal ulcer disease. N Engl J Med 286:1212–1213, 1972

    Google Scholar 

  71. Fung WP, Tye CY: Effect of smoking on gastric acid secretion. Austr NZ J Med 3:251–254, 1973

    Google Scholar 

  72. Whitecross DP, Clarke AD, Piper DW: The effect of cigarette smoking on human gastric secretion. Scand J Gastroenterol 9:399–403, 1974

    Google Scholar 

  73. Menguy R: Gastric mucus and the gastric mucous barrier. Am J Surg 117:806–812, 1969

    Google Scholar 

  74. Cooke AR: Mucosal resistance and corticosteroids. Gastroenterology 53:506, 1967

    Google Scholar 

  75. Heatley NG: Muco-substance as a barrier to diffusion. Gastroenterology 37:313–317, 1959

    Google Scholar 

  76. Chvasta TE, Cooke AR: The effect of several ulcerogenic drugs on the canine gastric mucosal barrier. J Lab Clin Med 79:302–315, 1972

    Google Scholar 

  77. Weisbrodt NW, Kienzle M, Cooke AR: Comparative effects of aliphatic alcohols on the gastric mucosa. Proc Soc Exp Biol Med 142:450–454, 1973

    Google Scholar 

  78. Cooke AR, Kienzle MG: Studies of anti-inflammatory drugs and aliphatic alcohols on antral mucosa. Gastroenterology 66:56–62, 1974

    Google Scholar 

  79. Konturek SJ, Solomon TE, McCreight WG, Johnson LR, Jacobson ED: Effect of nicotine on gastrointestinal secretions. Gastroenterology 60:1098–1105, 1971

    Google Scholar 

  80. Murray HS, Strottman MP, Cooke AR: Effect of several drugs on gastric potential difference. Br Med J 1:19–21, 1974

    Google Scholar 

  81. Bynum TE, Solomon TE, Johnson LR, Jacobson ED: Inhibition of pancreatic secretion in man by cigarette smoking. Gut 13:361–365, 1972

    Google Scholar 

  82. Read NW, Greech P: Effect of cigarette smoking on competence of the pylorus. Br Med J 3:313–316, 1973

    Google Scholar 

  83. Davenport HW: Damage to the gastric mucosa: Effects of salicylates and stimulation Gastroenterology 49:189–196, 1965

    Google Scholar 

  84. Davenport HW: Gastric mucosal hemorrhage in dogs: Effects of acid, aspirin and alcohol. Gastroenterology 56:439–449, 1969

    Google Scholar 

  85. Ivey KJ, Morrison S, Gray C: Effect of salicylates on the gastric mucosal barrier in man. J Appl Physiol 33:81–85, 1972

    Google Scholar 

  86. Geall MG, Phillips SF, Summerskill WHJ: Profile of gastric potential differences in man: Effects of aspirin, alcohol, bile and endogenous acid. Gastroenterology 58:437–443, 1970

    Google Scholar 

  87. Cooke AR, Hunt JN: Absorption of acetylsalicylic acid from unbuffered and buffered gastric contents. Am J Dig Dis 15:95–102, 1970

    Google Scholar 

  88. Cooke AR, Hunt JN: The effect of pH on the gastric absorption of aspirin. Guy's Hosp Rep 120:221–228, 1971

    Google Scholar 

  89. Hingson DJ, Ito S: Effect of aspirin and related compounds on the fine structure of mouse gastric mucosa. Gastroenterology 61:156–177, 1971

    Google Scholar 

  90. Brodie DA, Chase BJ: Role of gastric acid in aspirin-induced gastric irritation in the rat. Gastroenterology 53:604–610, 1967

    Google Scholar 

  91. Douthwaite AH, Lintott GAM: Gastroscopic observation of the effect of aspirin and certain other substances on the stomach. Lancet 2:1222–1225, 1938

    Google Scholar 

  92. Thorsen WB, Western D, Tanaka Y, Morrissey JF: Aspirin injury to the gastric mucosa: Gastrocamera observations of the effect of pH. Arch Intern Med 121:499–506, 1968

    Google Scholar 

  93. Hurley TW, Crandall LA: The effect of salicylates upon the stomach of dogs. Gastroenterology 46:36–43, 1964

    Google Scholar 

  94. Jabbari M, Valberg LS: Role of acid secretion in aspirin-induced gastric mucosal injury. Can Med Assoc J 102:178–181, 1970

    Google Scholar 

  95. St John DJB, McDermott FT: Influence of achlorhydria on aspirin-induced occult gastrointestinal blood loss: Studies in Addisonian pernicious anemia. Br Med J 2:450–452, 1970

    Google Scholar 

  96. Smith MJH: The Salicylates. MJH Smith, PK Smith (eds). London, Interscience, p 235, 1966

    Google Scholar 

  97. Salter RH: Aspirin and gastrointestinal bleeding. Am J Dig Dis 13:38–58, 1968

    Google Scholar 

  98. Holt PR: Measurement of gastrointestinal blood loss in subjects taking aspirin. J Lab Clin Med 56:717–726, 1960

    Google Scholar 

  99. Leonards JR, Levy G: Reduction or prevention of aspirin-induced occult gastrointestinal blood loss in man. Clin Pharmacol Ther 10:571–575, 1969

    Google Scholar 

  100. Bouchier IAD, Williams HS: Determination of fecal blood loss after combined alcohol and sodium acetylsalicylate intake. Lancet 1:178–180, 1969

    Google Scholar 

  101. Leonards JR: Aspirin and gastrointestinal blood loss. Gastroenterology 44:617–619, 1963

    Google Scholar 

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  1. Department of Internal Medicine, Veterans and University Hospitals, University of Iowa, Iowa City, Iowa

    Allan R. Cooke MD

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Cooke, A.R. The role of the mucosal barrier in drug-induced gastric ulceration and erosions. Digest Dis Sci 21, 155–164 (1976). https://doi.org/10.1007/BF01072063

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