Skip to main content
SpringerLink
Log in

A study of intestinal function and morphology in nonspecific ulcerative colitis in acute phase and remission in India

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Smallintestinal functions and villous morphology were studied in 32 cases of nonspecific ulcerative colitis—22 in acute phase and 10 in remission. In the acute phase, mild steatorrhea was detected in 7 of 22 cases and abnormald-xylose excretion in 8 of 18 cases. Significant morphologic changes in intestinal mucosa were present in 6 of 17 cases in the acute phase. Radiologically, a mild deficiency pattern was detected in 6 of the 12 cases. Malabsorptive derangement observed in the acute phase disappeared during remission. No malabsorptive or structural derangement was detected in cases with long remission. No motility disturbances were detected in any case. Intestinal dysfunction and morphologic changes correlated well with the severity of the disease. Anemia did not seem to play any role in the genesis of malabsorption, and hypoproteinemia showed some correlation with fecal fat excretion only.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mackie TT: Medical management of chronic ulcerative colitis. JAMA 111:2071–2076, 1938

    Google Scholar 

  2. Manousos ON, Salem SN: Abnormal motility of the small intestine in ulcerative colitis. Gastroenterologia 104:249–257, 1965

    Google Scholar 

  3. Groen J: The absorption of glucose from small intestine in deficiency disease. N Engl J Med 218:247–253, 1938

    Google Scholar 

  4. Elsom KA, Dickey FG, Chornock FW: Functional disturbances of the small intestine in chronic ideopathic ulcerative colitis. Am J Dig Dis 9:74–76, 1942

    Google Scholar 

  5. Zetzel L, Banks BM: Intestinal absorption of an aminoacid mixture in patients with chronic ideopathic ulcerative colitis and enterocolitis. Am J Dig Dis 9:350–352, 1942

    Google Scholar 

  6. Yueyama K, Giansiracusa JE, Althausen TL Harper HA: Alterations of intestinal absorption in ulcerative colitis and in intestinal hypermotility: modifications of these alterations in ulcerative colitis by Tween 80, ACTH and cortisone. Gastroenterology 23:143–154, 1953

    Google Scholar 

  7. Sandweiss DJ, Levy SH: Gastrointestinal absorption with oleic acid131I and L-methionine-35s in patients with ulcerative colitis. Proc Soc Exp Biol NY 95:259–261, 1957

    Google Scholar 

  8. Levy SH, Sandweiss DJ, Gagliardi RA, Feigelson HH: Proceedings of the World Congress of Gastroenterology and Fifth-Ninth Annual Meeting of the American Gastroenterological Association. Vol 1. Baltimore, Williams & Wilkins Co, 1958, p 445

    Google Scholar 

  9. Ruffin JM, Keever IC, Chears C Jr, Shingleton WW, Baylin GJ, Isley JK, Sanders AP: Further observation on use of131I-labeled lipids in the study of disease of the gastrointestinal tract. Gastroenterology 34:484–490, 1958

    Google Scholar 

  10. Pimparkar BD, Tulsky EG, Kalser MH, Bockus HL: Correlation of radioactive and chemical fat in various malabsorption syndrome studies in (I). Non-specific regional enteritis. (II). Ch. idiopathic ulcerative colitis. (III). Hepatobiliary disorders. (IV). Pts. with gastric surgery. J Postgrad Med 10:38–113, 1964

    Google Scholar 

  11. Salem SN, Truelove SC: Small intestinal and gastric abnormalities in ulcerative colitis. Br Med J 1:827–831, 1965

    Google Scholar 

  12. Salem SN, Truelove SC, Richards WCD: Small intestinal and gastric changes in ulcerative colitis: a biopsy study. Br Med J 1:394–398, 1964

    Google Scholar 

  13. Truelove SC, Witts LJ: Cortisone in ulcerative colitis: final report on a therapeutic trial. Br Med J 2:1041–1048, 1955

    Google Scholar 

  14. Van-de-Kamer JH, ten Bokkel Huinink H, Weyers HA: A rapid method for the determination of fat in faeces. J Biol Chem 177:347–355, 1949

    Google Scholar 

  15. Roe JH, Rice EW: Photometric method for determination of free pentoses in animal tissues. J Biol Chem 173:507–512, 1948

    Google Scholar 

  16. Crosby WH, Kugler HW: Intraluminal biopsy of the small intestine: the intestinal biopsy capsule. Am J Dig Dis 2:236–241, 1957

    Google Scholar 

  17. Rubin CE, Dobbins WO, III: Peoral biopsy of the small intestine: a review of its diagnostic usefulness. Gastroenterology 49:676–697, 1965

    Google Scholar 

  18. Burman NN, Sehgal AK, Chakravarti RN, Sodhi JS, Chhuttani PH: Morphological and absorption studies of small intestine in hookworm infestation (ankylostomiasis). Indian J Med Res 58:317–325, 1970

    Google Scholar 

  19. Baker SJ, Ignatius M, Mathan VI, Vaish SK, Chacko CC: Intestinal biopsy in tropical sprue, Intestinal Biopsy. Ciba Foundation Study Group No. 14. Boston, Little Brown & Co, 1962, pp 84–99

    Google Scholar 

  20. Sprinz H, Sribhibhadh R, Gangarosa EJ, Benyajati C, Kundel D, Halsted S: Biopsy of small bowel of Thai people, with special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Am J Clin Path 38:43–51, 1962

    Google Scholar 

  21. Struthers JE Jr, Singleton JW, Kern F Jr: Intestinal lactase deficiency in ulcerative colitis and regional ileitis. Ann Intern Med 63:221–228, 1965

    Google Scholar 

  22. Frazer AC, Hood C, Montgomery RD, Davies AG, Schnider R, Carter PA, Goodhart J: Carbohydrate intolerance in ulcerative colitis. Lancet 1:503–505, 1966

    Google Scholar 

  23. Brock JF: Dietary protein in relation to man's health. Fed Proc 20:61–65, 1961

    Google Scholar 

  24. Trowell HC, Davies JNP, Dean RFA: Kwashiorkor. London, Edward Arnold & CO, 1954, p 117

    Google Scholar 

  25. Deo MG, Ramalingaswami V: Absorption of Co58 labeled cyanocobalamin in protein deficiency: an experimental study in rhesus monkey. Gastroenterology 46:167–174, 1964

    Google Scholar 

  26. Sehgal AK, Vasdev SC, chakravarti RN, Mehta SK: A study of intestinal functions in experimental hypoproteinaemia in Rhesus monkey. Proceedings of the XI. International Congress on Internal Medicine, 1972, pp 362–364

  27. Chitis J, Tripathy K, Mayorol G: Malabsorption in the tropics: tropical sprue versus primary protein malnutrition: vitamin B12 and folic acid studies. Am J Clin Nutr 20:1206–1211, 1967

    Google Scholar 

  28. Chuttani HK, Mehra ML, Misra RC: Small bowel in hypoproteinaemia states. Scand J Gastroenterol 3:529–536, 1969

    Google Scholar 

  29. Rawson A, Rosenthal FD: The mucosa of the stomach and small intestine in iron deficiency. Lancet 1:730–731, 1960

    Google Scholar 

  30. Halsted JA, Prasad AS, Nadimi M: Gastrointestinal function in iron deficiency anaemia. Arch Intern Med 116:253–256, 1965

    Google Scholar 

  31. Sehgal AK, Aikat BK, Chhuttani PN: Mucosal changes in small intestine in various diseases: an autopsy study. India J Med Res 58:216–222, 1970

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    K. R. Chakravarti MD,  A. K. Sehgal MD, MAMS, R. N. Chakravarti MB, MAMS, PhD & P. N. Chnuttani MD, FAMS

Authors
  1. K. R. Chakravarti MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. K. Sehgal MD, MAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. N. Chakravarti MB, MAMS, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. N. Chnuttani MD, FAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chakravarti, K.R., Sehgal, A.K., Chakravarti, R.N. et al. A study of intestinal function and morphology in nonspecific ulcerative colitis in acute phase and remission in India. Digest Dis Sci 18, 191–198 (1973). https://doi.org/10.1007/BF01071972

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01071972

Keywords

Search

Navigation