Abstract
It has been suggested that the Y chromosome of DBA/1BBg mice makes an incremental contribution to their aggressive behavior and to that of the C57BL/10 ♀×DBA/1 ♂ F 1 hybrids. To test this hypothesis, a congenic stock of C57BL/10 with the DBA/1 Y chromosome was developed by the backcross system of breeding; the stock is designated C57BL/10-Y1. There were no significant differences in aggressive behavior between the congenic C57BL/10 and C57BL/10-Y1. However, the hybrid B10D1 F 1 and D1B10-Y1 F 1 had identical aggression scores, and both of these were more aggressive than the hybrid D1B10 F 1 . These findings support the hypothesis that there is an interaction between DBA/1 Y chromosomes and autosomes in the development of intermale aggression of these mice.
This is a preview of subscription content, log in via an institution to check access.
References
Ciaranello, R. D., Lipsky, A., and Axelrod, J. (1974). Association between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse sublines.Proc. Natl. Acad. Sci. 71:3006–3008.
Eleftheriou, B. E., Bailey, D. W., and Denenberg, V. H. (1974). Genetic analysis of fighting behavior in mice.Physiol. Behav. 13:773–777.
Elias, J. W., Elias, M. F., and Schlager, G. (1975). Aggresive social interactions in mice genetically selected for blood pressure extremes.Behav. Biol. 13:155–166.
Fuller, J. L., and Collins, R. L. (1968). Audiogenic seizure prone (asp): A gene affecting behavior in linkage group VIII of the mouse.Science 162:1137–1139.
Fuller, J. L., Easler, C., and Smith, M. E. (1950). Inheritance of audiogenic seizure susceptibility in the mouse.Genetics 35:622–632.
Ginsburg, B. E. (1967). Genetic parameters in behavioral research. In Hirsch, J. (ed.),Behavior-Genetic Analysis, McGraw-Hill, New York, pp. 135–153.
Ginsburg, B. E. (1969). Intra-uterine effects on behavioral capacities in mice. Paper presented at the symposium on the Effects of Intra-uterine Experience, XIX International Congress of Psychology, London.
Ginsburg, B. E., and Allee, W. C. (1942). Some effects of conditioning on social dominance and subordination in inbred strains of mice.Physiol. Zool. 15:485–506.
Green, E. L. (1966). Breeding systems. In Green, E. L. (ed.),Biology of the Laboratory Mouse, 2nd ed., McGraw-Hill, New York, pp. 11–22.
Haber, S. B., and Simmel, E. C. (1976). Tail rattling and agonistic behavior in mice: Coincidental or causal.Bull. Psychon. Soc. 7:84–86.
Hahn, M. E., Haber, S. B., and Fuller, J. L. (1973). Differential agonistic behavior in mice selected for brain weight.Physiol. Behav. 10:759–762.
Hay, D. A. (1975). Y chromosome and aggression in mice.Nature 255:658.
Hyde, J., and Ebert, P. D. (1976). Correlated response in selection for aggressiveness in female mice. I. Male aggression.Behav. Genet. 6:421–428.
Jumonville, J. E. (1968). Influence of genotype-treatment interaction in studies of “emotionality” in mice. Ph.D. dissertation, University of Chicago.
Kessler, S., Elliott, G. R., Orenberg, E. K., and Barachas, J. D. (1977). A genetic analysis of aggressive behavior in two strains of mice.Behav. Genet. 7:313–321.
Lagerspetz, L. (1971). Genetic and social cause of aggressive behavior in mice.Scand. J. Psychol. 2:167–173.
Orenberg, E. K., Renson, J., Elliott, G. R., Barchas, J. D., and Kessler, S. (1975). Genetic determination of aggressive behavior and brain cyclic AMP.Psychopharm. Comm. 1:99–107.
St. John, R. D. (1973). Genetic analysis of tail rattling in the mouse.Nature 241:549–551.
Scott, J. P. (1942). Genetic differences in the social behavior of inbred strains of mice.J. Hered. 33:11–15.
Selmanoff, M. K., Jumonville, J. E., Maxson, S. C., and Ginsburg, B. E. (1975). Evidence for a Y chromosomal contribution to an aggressive phenotype in inbred mice.Nature 253:529–530.
Selmanoff, M. K., Maxson, S. C., and Ginsburg, B. E. (1976). Chromosomal determinants of intermale aggressive behavior in inbred mice.Behav. Genet. 6:53–69.
Selmanoff, M. K., Goldman, B. D., Maxson, S. C., and Ginsburg, B. E. (1977). Correlated effects of the Y-chromosome on developmental changes in testosterone levels and intermale aggression.Life Sci. 20:359–366.
Southwick, C. H., and Clark, L. H. (1968). Interstrain differences in aggressive behavior and exploratory activity of inbred mice.Commun. Behav. Biol. 1:49–59.
Sze, P. Y., and Maxson, S. C. (1975). Involvement of corticosteroids in acoustic induction of audiogenic seizure susceptibility in mice.Psychopharmacology 45:79–82.
Vale, J. R., Vale, C. A., and Harley, J. P. (1971). Interactions of genotype and population number with regard to aggressive behavior, social grooming, and adrenal and gonadal weight in male mice.Commun. Behav. Biol. 6:209–221.
Whitney, G. (1973). Vocalization of mice influenced by a single gene in heterogeneous populations.Behav. Genet. 3:57–64.
Winer, B. J. (1962).Statistical Principles in Experimetal Design, Plenum, New York.
Wright, S. (1963). Genic interaction. In Burdette, W. J. (ed.),Methodology in Mammalian Genetics, Holden-Day, San Francisco, pp. 159–192.
Author information
Authors and Affiliations
Additional information
This research was supported by NIMH Grant 28021-02 and NICHHD Grant 11220-01
Rights and permissions
About this article
Cite this article
Maxson, S.C., Ginsburg, B.E. & Trattner, A. Interaction of Y-chromosomal and autosomal gene(s) in the development of intermale aggresiion in mice. Behav Genet 9, 219–226 (1979). https://doi.org/10.1007/BF01071302
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01071302