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Familial pseudomembranous colitis and its relation to lincomycin therapy

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Abstract

Severe pseudomembranous colitis was observed in 3 members of a single family: the father and 2 of his children. 2 of the affected family members received the antibiotic lincomycin prior to the onset of their symptoms. The findings in this family raise the possibility that antibiotic-induced pseudomembranous colitis in some patients may be the result of a pharmacogenetic interaction.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., 75235, Dallas, Texas

    Mary Jo E. Harrod PhD,  Michael S. Brown MD & Joseph L. Goldstein MD

  2. Department of Pathology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., 75235, Dallas, Texas

    Arthur G. Weinberg MD

Authors
  1. Mary Jo E. Harrod PhD
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  2. Michael S. Brown MD
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  3. Arthur G. Weinberg MD
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  4. William N. Harkness MD
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  5. Joseph L. Goldstein MD
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Additional information

Supported by grants from the National Institutes of Health (GM 19258) and from the Upjohn Co. Dr. Brown is an Established Investigator of The American Heart Association. Dr. Goldstein is the recipient of USPHS Research Career Development Award 5 KO4 GM 70277.

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Harrod, M.J.E., Brown, M.S., Weinberg, A.G. et al. Familial pseudomembranous colitis and its relation to lincomycin therapy. Digest Dis Sci 20, 808–812 (1975). https://doi.org/10.1007/BF01070948

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  • DOI: https://doi.org/10.1007/BF01070948

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