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Evaluation of endoscopic examination of colon tumors in rats

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Abstract

This study is an evaluation of the use of endoscopic examination to detect MNNG-induced large-bowel tumors in rats. The smallest human fiberbronchoscope was used as a colonoscope for the rats and the full length of the distal large bowel was visualized. The correct diagnosis rate in all rats with and without large-bowel tumors was 94%. Of rats with colon tumors, 85% were correctly diagnosed endoscopically. Even tumors 1 or 2 mm in diameter were detected. The examination was easy and reliable. This procedure may be an adjunct in experimental work with this and other animal models of colon cancer.

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Authors and Affiliations

  1. Naylor Dana Institute for Disease Prevention, American Health Foundation, 10595, Valhalla, New York

    Tomio Narisawa MD, DSc (a visiting investigator at the Naylor Dana Institute for Disease Prevention American Health Foundation), Ching-Quo Wong BS & John H. Weisburger PhD

Authors
  1. Tomio Narisawa MD, DSc
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  2. Ching-Quo Wong BS
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  3. John H. Weisburger PhD
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Additional information

Supported in part by contract NO1-CP-43378 and grant CA-15400 from the National Cancer Institute, NIH, US Public Health Service.

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Narisawa, T., Wong, CQ. & Weisburger, J.H. Evaluation of endoscopic examination of colon tumors in rats. Digest Dis Sci 20, 928–934 (1975). https://doi.org/10.1007/BF01070878

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  • DOI: https://doi.org/10.1007/BF01070878

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