Skip to main content
SpringerLink
Log in

Commentary: A behavioral, psychopharmacological, and neurochemical update on the flinders sensitive line rat, a potential genetic animal model of depression

  • Published:
Behavior Genetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Campbell, B. A., Lytle, L. D., and Fibiger, H. C. (1969). Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat.Science 166:635–637.

    Google Scholar 

  • Coyle, J. T., and Yamamura, H. I. (1976). Neurochemical aspects of ontogenesis of cholinergic neurons in the rat brain.Brain Res. 118:429–440.

    Google Scholar 

  • Crocker, A. D., and Overstreet, D. H. (1990). Changes in dopamine sensitivity in rats selectively bred for differences in cholinergic function.Pharmacol. Biochem. Behav. (in press).

  • Daws, L. C., Schiller, G. D., Overstreet, D. H., and Orbach, J. (1990). Early development of muscarinic supersensitivity in a genetic animal model of depression.Neuropsychopharmacology (in press).

  • Gallaher, D. W., and Gionet, S. (1990). Dissociation of ataxic and anti-convulsant effects of a diazepam in DS and DR mice suggests different underlying mechanisms. Presented at 20th meeting of Behavior Genetics Association, France, June 6–9.

  • Janowsky, D. S., and Risch, S. C. (1987). Role of actetylcholine mechanisms in affective disorders. In Meltzer, H. Y. (ed.),Psychopharmacology. The Third Generation of Progress, Raven Press, New York, pp. 527–534.

    Google Scholar 

  • Mendlewicz, J., Kerkhofs, M., Hoffmann, G., and Linkowski, P. (1984). Dexamethasone suppression test and REM sleep in patients with major depressive disorder.Br. J. Psychiat. 145:383–388.

    Google Scholar 

  • Nurnberger, J. I., Jr. Jimerson, D. C., Simmons-Alling, S., Tamminga, C., Nadi, N. S., Lawrence, D., Sitaram, N., Gillin, J. C., and Gershon, E. S. (1983). Behavioral, physiological and neuro-endocrine response to arecoline in normal twins and well state bipolar patients.Psychiat. Res. 9:191–202.

    Google Scholar 

  • Overstreet, D. H. (1986). Selective breeding for increased cholinergic function: Development of a new animal model of depression.Biol. Psychiat. 21:49–58.

    Google Scholar 

  • Overstreet, D. H., and Russell, R. W. (1982). Selective breeding for sensitivity to DFP. Effects of cholinergic agonists and antagonists.Psychopharmacology 78:150–155.

    Google Scholar 

  • Overstreet, D. H., and Russell, R. W. (1984). Selective breeding for differences in cholinergic function: Sex differences in the genetic regulation of sensitivity to the anticholinesterase, DFP.Behav. Neural Biol. 40:227–238.

    Google Scholar 

  • Overstreet, D. H., Russell, R. W., Crocker, A. D., and Schiller, G. D. (1984). Selective breeding for differences in cholinergic function: Pre- and post-synaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.Brain Res. 294:327–332.

    Google Scholar 

  • Overstreet, D. H., Russell, R. W., Crocker, A. D., Gillin, J. C., and Janowsky, D. S. (1988). Genetic and pharmacological models of cholinergic supersensitivity and affective disorders.Experientia 44:465–472.

    Google Scholar 

  • Overstreet, D. H., Double, K., and Schiller, G. D. (1989). Antidepressant effects of rolipram in a genetic animal model of depression: Cholinergic supersensitivity and weight gain.Pharmacol. Biochem. Behav. 34:691–696.

    Google Scholar 

  • Pepe, S., Overstreet, D. H., and Crocker, A. D. (1988). Enhanced benzodiazepine responsiveness in rats with increased cholinergic function.Pharmacol. Biochem. Behav. 31:15–20.

    Google Scholar 

  • Russell, R. W., and Overstreet, D. H. (1987). Mechanisms underlying sensitivity to organophosphorus anticholinesterase agents.Prog. Neurobiol. 28:97–129.

    Google Scholar 

  • Schiller, G. D., Orbach, J., and Overstreet, D. H. (1988). Effects of intracerebroventricular administration of site-selective muscarinic drugs in rats genetically selected for differing cholinergic sensitivity. Presented at meeting of Australasian Society of Clinical and Experimental Pharmacology, Adelaide, December.

  • Shiromani, P. J., Gillin, J. C., and Hendrickson, P. (1987). Acetylcholine and the regulation of REM sleep—Basic mechanisms and clinical implications for affective illness and narcolepsy.Annu. Rev. Pharmacol. Toxicol. 27:137–156.

    Google Scholar 

  • Shiromani, P. J., Overstreet, D. H., Levy, D., Goodrich, C. A., Campbell, S. S., and Gillin, J. C. (1988). Increased REM sleep in rats selectively bred for cholinergic hyperactivity.Neuropsychopharmacology 1:127–133.

    Google Scholar 

  • Sitaram, N., Dube, S., Jones, D., Pohl, R., and Gershon, S. (1984). Acetylcholine and alphal-adrenergic sensitivity in the separation of depression and anxiety.Psychopathology 17 (Suppl. 3):24–39.

    Google Scholar 

  • Sitaram, N., Dube, S., Keshavan, M., Davies, A., and Reynal, P. (1987). The association of supersensitive cholinergic REM-induction and affective illness within pedigrees.J. Psychiat. Res. 21:487–497.

    Google Scholar 

  • Wallis, E., Overstreet, D. H., and Crocker, A. D. (1988). Selective breeding for increased cholinergic function: Increased serotonergic sensitivity.Pharmacol. Biochem. Behav. 31:345–350.

    Google Scholar 

  • Weissman, M. M., Gammon, G. D., John, K., Merikangas, K. R., Warner, V., Prusoff, B. A., and Sholonski, D. (1987). Children of depressed parents.Arch. Gen. Psychiat. 44:847–853.

    Google Scholar 

  • Wolff, E. A., III, Putnam, F. W., and Post, R. M., (1985) Motor activity and affective illness. The relationship of amplitude and temporal distribution to changes in affective state.Arch. Gen. Psychiat. 42:288–294.

    Google Scholar 

Download references

Author information

Author notes

  1. David H. Overstreet

    Present address: Center for Alcohol Studies, University of North Carolina, 27514, Chapel Hill, North Carolina

Authors and Affiliations

  1. School of Biological Sciences, Flinders University of South Australia, GPO 2100, 5001, Adelaide, South Australia, Australia

    David H. Overstreet

Authors
  1. David H. Overstreet
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was reported in part by research gives from the National Health and Medicine Research Council (Australia), the Australian Research Council, and the Flinders University Research Budget.

This commentary derives from a presentation made at a workshop on “Genetic Aspects of Anxiety/Depression in Humans and Rats: Nature of the Syndrome(s) and Veracity of the Model(s),” which was held during the 20th annual BGA meeting, June 1990, in Aussois, France.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Overstreet, D.H. Commentary: A behavioral, psychopharmacological, and neurochemical update on the flinders sensitive line rat, a potential genetic animal model of depression. Behav Genet 21, 67–74 (1991). https://doi.org/10.1007/BF01067667

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01067667

Keywords

Search

Navigation