Abstract
It has often been noted that the correlation between dizygotic (DZ) twins is smaller than predicted from the monozygotic (MZ) correlation under a simple additive genetic model. Possible genetic explanations of this finding are considered. It is shown that duplicate gene interactions between pairs of moderately frequent alleles at polygenic loci are sufficient to produce surprisingly small (approximately 0.12) genetic correlations between siblings.
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This research was supported by NIH Grants AG04954, GM30250, and GM32732 and ADAMHA Grants AA06781 and MH40828.
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Eaves, L.J. Dominance alone is not enough. Behav Genet 18, 27–33 (1988). https://doi.org/10.1007/BF01067073
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DOI: https://doi.org/10.1007/BF01067073