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Linear pharmacokinetic models: Geometric construction to determine transfer and elimination rate constants

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Abstract

It is shown that, in linear pharmacokinetics, the blood concentration-time curves determine the model to a certain extent, but not completely. Intervals of indetermination for the parameters are calculated and represented by a simple graph. Each additional measurement (of unchanged drug in urine, of metabolites in blood or in urine) will help to reduce these intervals. A unique model can be elaborated only in certain cases, or with additional hypotheses. Utilizing data from the literature, numerical applications are detailed.

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  1. U. E. R. de Saint-Quentin, 48 bld Raspail, 02100, Saint Quentin, France

    Nguyen Phong Chau

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  1. Nguyen Phong Chau
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Chau, N.P. Linear pharmacokinetic models: Geometric construction to determine transfer and elimination rate constants. Journal of Pharmacokinetics and Biopharmaceutics 5, 147–159 (1977). https://doi.org/10.1007/BF01066218

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  • DOI: https://doi.org/10.1007/BF01066218

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