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Evaluation of equilibrium dialysis volume shifts: A comment

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Abstract

Previous authors have presented in this journal an equation defining the fractional shift in volume (fs)as a general equation implying applicability to a wide variety of circumstances. The equation concerned actually applies only when the starting volumes before dialysis are equal. A better general definition is given by fs=(volume shift)/(starting volume of protein solution).

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References

  1. J. J. Lima, J. J. MacKichan, N. Libertin, and J. Sabino. Influence of volume shifts on drug binding during equilibrium dialysis: correction and alternation.J. Pharmacokin. Biopharm. 11:483–498 (1983).

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Authors and Affiliations

  1. Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, 32610, Gainesville, FL

    Stephen H. Curry & Oliver Y. -P. Hu

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  1. Stephen H. Curry
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  2. Oliver Y. -P. Hu
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Curry, S.H., Hu, O.Y.P. Evaluation of equilibrium dialysis volume shifts: A comment. Journal of Pharmacokinetics and Biopharmaceutics 12, 463–465 (1984). https://doi.org/10.1007/BF01062669

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  • DOI: https://doi.org/10.1007/BF01062669

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