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Influence of food on the kinetics of 8-methoxypsoralen in serum and suction blister fluid in psoriatic patients

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Summary

The influence of food on the kinetics of 8-methoxypsoralen (8-MOP) in serum and suction blister fluid was evaluated in a cross-over study in 19 psoriatic patients under PUVA treatment. The peak serum concentration of 8-MOP was reached 1.5 h after ingestion on an empty stomach, and in suction blister fluid the maximum concentration was already present in the first sample taken after 2 h, the time when UVA radiation was given. The postprandial kinetics of 8-MOP in serum and suction blister fluid differed, the highest levels being reached, respectively, at 2.4 and 3 h after intake, i.e. in both body fluids after irradiation had started. The side effects of 8-MOP, such as nausea and dizziness, in the two groups were similar. The present results indicate that to optimize the therapeutic effect of PUVA in individual patients, 8-MOP should be given on an empty stomach.

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References

  • Artuc M, Stuettgen G, Schalla W, Schaefer H, Gazith J (1979) Reversible binding of 5- and 8-methoxypsoralen to human serum proteins (albumin) and to epidermis in vitro. Br J Dermatol 101: 669–677

    Google Scholar 

  • Brown BW (1980) The cross-over experiment for clinical trials. Biometrics 36: 69–79

    Google Scholar 

  • Bush U, Schmid J, Koss FW, Zipp H, Zimmer A (1978) Pharmacokinetics and metabolite-pattern of 8-methoxypsoralen in man following oral administration as compared to the pharmacokinetics in rat and dog. Arch Dermatol Res 262: 255–265

    Google Scholar 

  • De Wolff FA, Herfst MJ, Edelbroek PM (1980) Determination of 8-methoxypsoralen in human serum and suction blister fluid. In: Oliver JS (ed) Forensic toxicology. Croom Helm, London, pp 67–70

    Google Scholar 

  • Ehrsson H, Nilsson SO, Ehrnebo M, Wallin I, Wennersten G (1979) Effect of food on kinetics of 8-methoxsalen. Clin Pharmacol Ther 25: 167–171

    Google Scholar 

  • Epstein JH, Farber EM et al (1979) Current status of oral PUVA therapy for psoriasis. J Am Acad Dermatol 1: 106–117

    Google Scholar 

  • Herfst MJ, van Rees H (1978) Suction blister fluid as a model for interstitial fluid in rats. Arch Dermatol Res 263: 325–334

    Google Scholar 

  • Herfst MJ, Edelbroek PM, De Wolff FA (1980) Determination of 8-methoxypsoralen in suction blister fluid and serum by High-Performance Liquid Chromatography. Clin Chem 26: 1825–1828

    Google Scholar 

  • Herfst MJ, Koot-Gronsveld EAM, De Wolff FA (1978) Serum levels of 8-methoxypsoralen in psoriasis patients using a new fluorodensitometric method. Arch Dermatol Res 262: 1–6

    Google Scholar 

  • Herfst MJ, De Wolff FA (1982) Difference in bioavailability between two brands of 8-methoxypsoralen and its impact on the clinical response in psoriatic patients. Br J Clin Pharmacol 13: 519–522

    Google Scholar 

  • Houwert-de Jong M, Gerards LJ, Tetteroo-Tempelman CAM, De Wolff FA (1981) May mothers taking acenocoumarol breast feed their infants? Eur J Clin Pharmacol 21: 61–64

    Google Scholar 

  • Kiistala U, Mustakallio KK (1967) Dermo-epidermal separation with suction. Electron microscopic and histochemical study of initial events of blistering in human skin. J Invest Dermatol 48: 466–477

    Google Scholar 

  • Kiistala U (1971) Proteins in suction blisters of human skin. Abstract European Society for Dermatological Research Meeting, 1971–1980; First Annual Meeting, Noordwijk aan Zee, Holland, p 15

    Google Scholar 

  • Melander A (1978) Influence of food on the bioavailability of drugs. Clin Pharmacokinet 3: 337–351

    Google Scholar 

  • Melski JW, Tanenbaum L, Parrish JA, Fitzpatrick TB, Bleich HL (1977) Oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial. J Invest Dermatol 68: 328–335

    Google Scholar 

  • Parrish JA, Fitzpatrick TB, Tanenbaum L, Pathak MA (1974) Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light. N Engl J Med 291: 1207–1212

    Google Scholar 

  • Roenigk HH, Martin JS (1977) Photochemotherapy for psoriasis. Arch Dermatol 113: 1667–1670

    Google Scholar 

  • Vermeer BJ, Reman FC, van Gent CM (1979) The determination of lipide and proteins in suction blister fluid. J Invest Dermatol 73: 303–305

    Google Scholar 

  • Wolff K, Fitzpatrick TB, Parrish JA, Gschnait F, Gilchrest B, Hönigsmann H, Pathak MB, Tanenbaum L (1976) Photochemotherapy for psoriasis with orally administered methoxsalen. Arch Dermatol 112: 943–950

    Google Scholar 

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Author notes

  1. M. J. Herfst

    Present address: Diaconessenhuis, Houtlaan 55, NL-2334 CK, Leiden, The Netherlands

Authors and Affiliations

  1. Department of Dermatology, University Hospital, Leiden, The Netherlands

    M. J. Herfst

  2. Laboratory of Toxicology, University Hospital, Leiden, The Netherlands

    F. A. De Wolff

Authors
  1. M. J. Herfst
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  2. F. A. De Wolff
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Herfst, M.J., De Wolff, F.A. Influence of food on the kinetics of 8-methoxypsoralen in serum and suction blister fluid in psoriatic patients. Eur J Clin Pharmacol 23, 75–80 (1982). https://doi.org/10.1007/BF01061380

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  • DOI: https://doi.org/10.1007/BF01061380

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