Skip to main content
SpringerLink
Log in

Kinetics of diphenylhydantoin elimination in rats

  • Published:
Journal of Pharmacokinetics and Biopharmaceutics Aims and scope Submit manuscript

Abstract

Concentrations of diphenylhydantoin (DPH) in the blood of male Sprague-Dawley rats after intravenous injection of 10 and 40 mg/kg 14C-DPHwere determined over a sufficiently wide range to permit comparison of rates of decline at the same absolute and relative concentrations. This comparison leads to the conclusion that the elimination of DPH in the rat cannot be described by first-order or simple Michaelis-Menten kinetics but that it is qualitatively consistent with product inhibition of DPH metabolism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. N. Gerber and K. Arnold. Studies on the metabolism of diphenylhydantoin in mice.J. Pharmacol. Exptl. Therap. 167: 77–90 (1969).

    CAS  Google Scholar 

  2. N. Gerber, W. L. Weller, R. Lynn, R. E. Rangno, B. J. Sweetman, and M. T. Bush. Study of dose-dependent metabolism of 5,5-diphenylhydantoin in the rat using new methodology for isolation and quantitation of metabolitesin vivo andin vitro.J. Pharmacol. Exptl. Therap. 178: 567–579 (1971).

    CAS  Google Scholar 

  3. P. G. Dayton, S. A. Cucinell, M. Weiss, and J. M. Perel. Dose dependence of drug plasma level decline in dogs.J. Pharmacol. Exptl. Therap. 158: 305–316 (1967).

    CAS  Google Scholar 

  4. K. Arnold and N. Gerber. The rate of decline of diphenylhydantoin in human plasma.Clin. Pharmacol. Therap. 11: 121–134 (1970).

    CAS  Google Scholar 

  5. N. Gerber and J. G. Wagner. Explanation of dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation.Res. Comm. Chem. Pathol. Pharmacol. 3: 455–466 (1972).

    CAS  Google Scholar 

  6. J. J. Ashley and G. Levy. Inhibition of diphenylhydantoin elimination by its major metabolite.Res. Comm. Chem. Pathol. Pharmacol. 4:297–306 (1972).

    CAS  Google Scholar 

  7. P. Borondy, T. Chang, and A. J. Glazko. Inhibition of diphenylhydantoin (DPH) hydroxylation by 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH).Fed. Proc. 31: 582 (abst.) (1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, 14214, Buffalo, New York

    John J. Ashley & Gerhard Levy

Authors
  1. John J. Ashley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerhard Levy
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by grant GM 19568 from the National Institutes of Health.

On leave from the School of Pharmacy, University of Sydney, Sydney, Australia.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ashley, J.J., Levy, G. Kinetics of diphenylhydantoin elimination in rats. Journal of Pharmacokinetics and Biopharmaceutics 1, 99–102 (1973). https://doi.org/10.1007/BF01059624

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01059624

Key words

Search

Navigation