Abstract
A simple method is presented by which one may determine if the absorption and the elimination rate constants are equal (in the one-compartment body model) using only plasma drug data. This method suggests the pertinent equation to calculate the relevent pharmacokinetic parameters.
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References
F. H. Dost.Grundlagen der Pharmakokinetik, 2. Gufl., G. Thieme, Stuttgart 1968, pp. 38–47.
M. Gibaldi and D. Perrier.Pharmacokinetics, Dekker, New York, 1975, pp. 33–43.
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Bialer, M. A simple method for determining whether absorption and elimination rate constants are equal in the one-compartment open model with first-order processes. Journal of Pharmacokinetics and Biopharmaceutics 8, 111–113 (1980). https://doi.org/10.1007/BF01059453
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DOI: https://doi.org/10.1007/BF01059453