Abstract
The present communication seeks to end a controversy created by a recent publication regarding the applicability of statistical moment principles for determination of mean residence time of drug in the body ¯tb.It is shown that the equation ¯tb=AUMC/AUC iscorrect when applied to pharmacokinetic systems in which the total drug elimination rate is directly proportional to the drug concentration in the systemic circulation, i.e., firstorder central elimination. More general equations for ¯tb in terms of elimination rate, amount eliminated, and amount in the body are presented along with demonstrations of their utility.
Similar content being viewed by others
References
D. O. Chanter. The determination of mean residence time using statistical moments: Is it correct?J. Pharmacokin. Biopharm. 13:93–100 (1985).
P. Veng-Pedersen and W. R. Gillespie. Mean residence time in peripheral tissue: A linear disposition parameter useful for evaluating a drug's tissue distribution.J. Pharmacokin. Biopharm. 12:535–544 (1984).
M. H. DeGroot.Probability and Statistics, Addison-Wesley, Reading, Massachusetts, 1975, pp. 77–90, 143–146.
K. Yamaoka, T. Nakagawa, and T. Uno. Statistical moments in pharmacokinetics.J. Pharmacokin. Biopharm. 6:547–558 (1978).
P. Veng-Pedersen and W. R. Gillespie. The mean residence time of drugs in the systemic circulation.J. Pharm. Sci. 74:791–792 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gillespie, W.R., Veng-Pedersen, P. The determination of mean residence time using statistical moments:It is correct . Journal of Pharmacokinetics and Biopharmaceutics 13, 549–554 (1985). https://doi.org/10.1007/BF01059336
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01059336