Abstract
Statistical comparisons were made between the relative mean concentrations of metabolites of aromatic compounds in bile (as estimated by a high-performance liquid chromatography/fluorescence detection method) and idiopathic liver lesions in English sole (Parophrys vetulus) from eleven Puget Sound sites. A significant positive correlation was found between prevalences of neoplasms, foci of cellular alteration, megalocytic hepatosis and total hepatic lesions and the concentrations of metabolites of aromatic compounds. These findings provide further evidence of the putative relationship between aromatic compounds and serious idiopathic liver diseases in bottom-dwelling fish.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Armed Forces Institute of Pathology (1968) Manual of Histologic Staining Methods. In: Luna, LG (ed) Third Edition. McGraw-Hill, New York, 258 pp
Day DE (1976) Homing behavior and population stratification in Central Puget Sound English sole (Parophrys vetulus). J Fish Res Board Can 33:278–282
Gossett RW, Brown DA, Young DR (1982) Predicting the bioaccumulation and toxicity of organic compounds.Coastal Water Research Project Biennial Report 1981–1982. (Southern California Coastal Water Research Project, Long Beach, CA 1982), pp 149–156
Gray P (1954) The microtomist's formulary and guide. Blakiston, New York
Kleinbaum DG, Kupper LL (1978) Applied Regression Analysis and other Multivariable Methods. Duxbury Press, Boston, MA, 556 pp
Krahn MM, Myers MS, Burrows DG, Malins DC (1984) Determination of metabolites of xenobiotics in bile of fish from polluted waterways. Xenobiotica 14:633–646
Krahn MM, Collier TK, Malins DC (1982) Aromatic hydrocarbon metabolites in fish: automated extraction and highperformance liquid Chromatographic separation into conjugate and nonconjugate fractions. J Chromatogr 236:441–452
Lewin R (1983) NAS study highlights chemical mutagens. Science 219:1304–1305
MacLeod WD Jr, Ramos LS, Friedman AJ, Burrows DG, Prohaska PG, Fisher DL, Brown DW (1981) Analysis of residual chlorinated hydrocarbons, aromatic hydrocarbons and related compounds in selected sources, sinks and biota of New York Bight. National Oceanic and Atmospheric Administration Tech Memo OMPA-6, 128 pp
Malins DC, Krahn MM, Brown DW, Rhodes LD, Myers MS, McCain BB, Chan S-L (1985) Toxic chemicals in marine sediment and biota from Mukilteo, Washington: Relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). J Natl Cancer Inst 74:487–494
Malins DC, McCain BB, Brown DW, Chan S-L, Myers MS, Landahl JT, Prohaska PG, Friedman AJ, Rhodes LD, Burrows DG, Gronlund WD, Hodgins HO (1984) Chemical pollutants in sediments and diseases of bottom-dwelling fish in Puget Sound, Washington. Environ Sci Technol 18:705–713
Malins DC, McCain BB, Brown DW, Sparks AK, Hodgins HO, Chan SL (1982) Chemical contaminants and abnormalities in fish and invertebrates from Puget Sound. National Oceanic and Atmospheric Administration Tech Memo OMPA-19, 168 pp
Malins DC, Krahn MM, Myers MS, Rhodes LD, Brown DW, Krone CA, McCain BB, Chan S-L (in press) Toxic chemicals in sediments and biota from a creosote-polluted harbor: Relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). Carcinogenesis
McCain BB, Myers MS, Varanasi U, Brown DW, Rhodes LD, Gronlund WD, Elliott DG, Palsson WA, Hodgins HO, Malins DC (1982) Pathology of two species of flatfish from urban estuaries in Puget Sound. Department of Commerce/EPA Interagency Energy/Environment, Research and Development Program Report (EPA-600/7-82-001), 100 pp
Mix MC, Schaffer RL (1983) Concentrations of unsubstituted polynuclear aromatic hydrocarbons in bay mussels (Mytilus edulis) from Oregon, USA. Mar Environ Res 9:193–209
Pierce KV, McCain BB, Weliings SR (1978) Pathology of hepatomas and other liver abnormalities in English soie (Parophrys vetulus) from the Duwamish River estuary, Seattle, WA. J Natl Cancer Inst 60:1445–1453
Pucknat AW (1981) Health Impacts of Polynuclear Aromatic Hydrocarbons. Noyes Data, Park Ridge, NJ
Sindermann CJ (1978) Pollution associated diseases and abnormalities of fish and shellfish: A review. Fishery Bulletin 76:717–749
Smith CE, Peck TH, Klauda RJ, McLaren JB (1979) Hepatomas in Atlantic tomcodMicrogadus tomcod (Walbaum) collected in the Hudson River estuary in New York. J Fish Diseases 2:313–319
Varanasi U, Gmur DJ (1981) Hydrocarbons and metabolites in English sole exposed simultaneously to [3H]benzo(a)pyrene and [14C]naphthalene in oil-contaminated sediment. Aquat Toxicol 1:49–67
Word JQ (1976) Biological comparison of grab sampling devices. In: Bascom, W. (ed) Annual Report, Southern, California Coastal Water Research Project, Long Beach, CA, pp 189–194
Zar JG (1974) Biostatistical Analysis. Prentice Hail, Englewood Cliffs, NJ. 620 pp
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krahn, M.M., Rhodes, L.D., Myers, M.S. et al. Associations between metabolites of aromatic compounds in bile and the occurrence of hepatic lesions in English sole (Parophrys vetulus) from Puget Sound, Washington. Arch. Environ. Contam. Toxicol. 15, 61–67 (1986). https://doi.org/10.1007/BF01055249
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01055249