Abstract
Newborn mink (Mustela vison) kits were administered 0.1 μg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg body weight, 1μg TCDD/kg body weight, 10μg epidermal growth factor (EGF)/ kg body weight, or 50 (μg EGF/kg body weight by intraperitoneal (i.p.) injection (10 ml/kg body weight) for 12 consecutive days to compare the effects of TCDD and EGF on body weight gains, time of eyelid opening, tooth eruption, and pelage development. A 1∶9 acetone-corn oil mixture and 0.85 NaCl served as vehicle controls for the TCDD and EGF groups, respectively. Mortality exceeded 50% at the higher doses of both TCDD and EGF, while at the lower doses, TCDD and EGF resulted in significant reduction of body weight gains. Additionally, EGF caused a significant decrease in the time of eyelid opening and retarded growth and development of the fur of the treated kits. TCDD had no discernible effects on the time of eyelid opening or hair growth. The time of tooth eruption was not significantly affected by either compound.
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Published with the approval of the Michigan Agricultural Experiment Station as Journal Article No. 12216.
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Aulerich, R.J., Bursian, S.J. & Napolitano, A.C. Biological effects of epidermal growth factor and 2,3,7,8-tetrachlorodibenzo-p-dioxin on developmental parameters of neonatal Mink. Arch. Environ. Contam. Toxicol. 17, 27–31 (1988). https://doi.org/10.1007/BF01055150
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DOI: https://doi.org/10.1007/BF01055150