Summary
Twelve adult patients in the records of 38 patients with histologically verified supratentorial low grade glioma showed recurrence at the Gifu University Hospital between 1980 and 1992. A mean period to recurrence from the initial surgery and postoperative radiation was 38 months. Six of these patients underwent intraoperative radiation therapy. The other six patients received chemotherapy with conventional cytoreductive surgery in three cases and additional external irradiation in three cases. The 2-year survival rate of the former patients was 83.8% and significantly higher than that of the latter ones, 16.7% (p < 0.05). Most cases showing recurrence of supratentorial low grade glioma were occurred locally, and dissemination or remote metastasis of the lesion were rare. The results revealed that the local control is important for recurrent tumors of supratentorial low grade gliomas. The effectiveness of the intraoperative radiation therapy as the second operation for the recurrent supratentorial benign glioma is discussed.
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References
Hara A, Hirayama H, Sakai N, Yamada H, Tanaka T, Mori H: Correlation between nucleolar organizer region staining and Ki-67 immunostaining in human gliomas. Surg Neurol 33: 320–324, 1990
Hoshino T, Prados M, Wilson CB, Cho KG, Lee KS, Davis RL: Prognostic implications of bromodeoxyuridine labeling index of human gliomas. J Neurosurg 71: 335–341, 1989
McCormack BM, Miller DC, Budzilovich GN, Voorhees GJ, Ransohoff J: Treatment and survival of low-grade astrocytoma in adults 1977–1988. Neurosurgery 31: 636–642, 1992
Piepmeier JM: Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres. J Neurosurg 67: 117–181, 1987
Soffietti R, Chio A, Giordana MT, Vasario E, Schiffer D: Prognostic factors in well-differentiated cerebral astrocytomas in the adult. Neurosurgery 24: 686–692, 1989
Vertosick FT, Selker RG, Arena VC: Survival of patients with wel-differentiated astrocytomas diagnosed in the era of computed tomography. Neurosurgery 28: 496–501, 1991
Whitton AC, Bloom HJG: Low grade glioma of the cerebral hemispheres in adults: a retrospective analysis of 88 cases. Int J Radiat Oncol Biol Phys 18: 783–786, 1990
Sakai N, Yamada H, Andoh T, Hirata T, Nishimura Y, Miwa Y, Shimizu K, Yanagawa S: Intraoperative radiation therapy for malignant glioma. Neurol Med Chir (Tokyo) 31: 702–707, 1991
Shibamoto Y, Kitakabu Y, Takahashi M, Yamashita J, Oda Y, Kikuchi H, Abe M: Supratentorial low-grade astrocytoma. Cancer 72: 190–195, 1993
Arita N, Taneda M, Hayakawa T: Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome. Acta Neurochir (Wien) 126: 84–92, 1994
Burger PC, Heinz ER, Shibata T, Kleihues P: Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 68: 698–704, 1988
Civitello LA, Packer RJ, Rorke LB, Siegel PA, Sutton LN, Schut L: Leptomeningeal dissemination of low-grade gliomas in childhood. Neurosurgery 38: 562–566, 1988
Perese DM, Stepian A, Nigogosyan G: Post-operative dissemination of astrocytoma of the spinal cord along the ventricle of the brain: a case report. J Neurosurg 16: 114–119, 1959
Garcia DM, Fulling KH, Marks JE: The value of radiation therapy in addition to surgery for astrocytomas of the adult cerebrum. Cancer 55: 919–927, 1985
Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 66: 1–22, 1987
Gutin PH, Phillips TL, Wara WM, Leibel SA, Hosobuchi Y, Levin VA, Weaver KA, Lamb S: Brachytherapy of recurrent malignant brain tumors with removable high-activity iodine-125 sources. J Neurosurg 60: 61–68, 1984
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Hara, A., Nishimura, Y., Sakai, N. et al. Effectiveness of intraoperative radiation therapy for recurrent supratentorial low grade glioma. J Neuro-Oncol 25, 239–243 (1995). https://doi.org/10.1007/BF01053157
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DOI: https://doi.org/10.1007/BF01053157