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The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction

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Summary

Tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of the multi member family of matrix metalloproteinases (MMPs). Since MMP function is fundamental to events that require tissue remodelling, TIMPs regulate normal biological processes by inhibiting MMPs, and are of importance in pathological conditions. In this chapter we review evidence for the suppressive role of TIMP-1 in the malignant progression of cancer and of its regulatory function in controlling invasion during blastocyst implantation and development.

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Authors and Affiliations

  1. Department of Oncology, University of Western Ontario, London Regional Cancer Centre, 790 Commissioners Road East, London, Ontario

    R. Khokha

  2. Amgen Institute, Ontario Cancer Institute, Departments of Immunology and Medical Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario

    P. Waterhouse

Authors
  1. R. Khokha
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  2. P. Waterhouse
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Khokha, R., Waterhouse, P. The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction. J Neuro-Oncol 18, 123–127 (1993). https://doi.org/10.1007/BF01050418

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