Summary
A data acquisition/control microcomputer system was interfaced to a commercial HPLC data transmission module. Control of substrate (ethanol) levels for four 7.5 L fermenters containing 100 g/L wet weight of the yeastCandida norvegensis was accomplished by employing intermittent, automated HPLC monitoring and a BASIC-encoded proportional integral policy for controlling substrate feed rates. Ethanol levels were maintained at 0.25, 0.50, 0.75 and 1.00% w/v.
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References
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Mathers, J.J., Dinwoodie, R.C., Talarovich, M. et al. Computer-linked HPLC system for feedback control of fermentation substrates. Biotechnol Lett 8, 311–314 (1986). https://doi.org/10.1007/BF01040855
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DOI: https://doi.org/10.1007/BF01040855