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Highly efficient conversion of (±)-mandelic acid to its (R)-(−)-enantiomer by combination of enzyme-mediated oxidation and reduction

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Summary

A novel method for total conversion of racemic mandelic acid into its (R)-enantiomer was developed. The method consists of enantioselective oxidation of (S)-(+)-mandelic acid byAlcaligenes bronchisepticus KU 1201 and NADH-dependent asymmetric reduction of resulting benzoylformic acid to (R)-mandelic acid with cell-free extract ofStreptococcus faecalis IFO 12964.

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Authors and Affiliations

  1. Department of Chemistry, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223, Japan

    Shigeo Tsuchiya, Kenji Miyamoto & Hiromichi Ohta

Authors
  1. Shigeo Tsuchiya
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  2. Kenji Miyamoto
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  3. Hiromichi Ohta
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Tsuchiya, S., Miyamoto, K. & Ohta, H. Highly efficient conversion of (±)-mandelic acid to its (R)-(−)-enantiomer by combination of enzyme-mediated oxidation and reduction. Biotechnol Lett 14, 1137–1142 (1992). https://doi.org/10.1007/BF01027017

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  • DOI: https://doi.org/10.1007/BF01027017

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