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Novel use of a perfluorocarbon for supplying oxygen to aerobic submerged cultures

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Summary

A novel method for supplying oxygen by using a perfluorocarbon as an oxygen carrier in submerged cultures was demonstrated. Oxygen was transferred to the aqueous phase by liquid-liquid contacting in a spray column fermentor. Advantages of using such a system for supplying oxygen are discussed.

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Abbreviations

F1 :

recirculation rate of PP9 through nozzle

PB :

back pressure at nozzle

SAPP9 :

oxygen concentration in PP9 in aerator as a percent of saturation when air equilibrated at the end of the exponential phase of growth

TF :

fermentation time to reach final cell concentration

VA :

air flow rate through sparger

Xe :

cell concentration at the end of the exponential phase of growth

XF :

final cell concentration

ØA :

gas (air) hold-up

ØL :

liquid (PP9) hold-up in aqueous system

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Authors and Affiliations

  1. Department of Chemical and Biochemical Engineering Rutgers, The State University of New Jersey, PO Box 909, 08854, Piscataway, NJ, USA

    Dominick Damiano & Shaw S. Wang

Authors
  1. Dominick Damiano
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  2. Shaw S. Wang
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Damiano, D., Wang, S.S. Novel use of a perfluorocarbon for supplying oxygen to aerobic submerged cultures. Biotechnol Lett 7, 81–86 (1985). https://doi.org/10.1007/BF01026673

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