Summary
By employing carbon limited fed batch techniques, fatty acids of length C8 to C12 were successfully employed as precursors for biosynthesis of A21978C antibiotics. The efficiency of incorporation was related to the length of the lipid precursor, with C10-C12 fatty acids being the preferred substrates.
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Huber, F.M., Berry, D.M., Pieper, R.L. et al. The synthesis of A21978C analogs byStreptomyces roseosporus cultivated under carbon limitation and fed fatty acids. Biotechnol Lett 12, 789–792 (1990). https://doi.org/10.1007/BF01022596
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DOI: https://doi.org/10.1007/BF01022596