Zusammenfassung
Bei 30 Patienten wurde während und nach transvesikaler Prostataresektion Blutverlust, fibrinolytische Plasmaaktivität, Prothrombin, partielle Thromboplastinzeit und Plasmafibrinogenspiegel gemessen. Zehn dieser Patienten erhielten Trans-4-(aminomethyl)-Cyclohexan-Carbonsäure (AMCHA), zehn Patienten einen Schlangengiftextrakt aus Bothrops Jararaca, zehn Patienten dienten als Kontrolle. Es zeigte sich, daß der Schlangengiftextrakt mit thrombinähnlicher Aktivität die intraoperative Blutung vermindert, ohne zu Veränderungen der Hämostase mit erhöhter Thromboemboliegefährdung zu führen. Die postoperative Hämaturie konnte dagegen mit Antifibrinolytika vermindert werden.
Summary
Blood loss, plasma fibrinolytic activity, prothrombin, P.T.T., and fibrinogen plasma levels were measured in 30 patients subjected to transvesical adenomectomy. These parameters were evaluated during 7 consecutive days after the operation. Ten patients received the antifibrinolytic substance (AMCHA), ten patients received Bothrops Jararaca venom extract, and ten patients served as controls. The results show that the coagulating fraction of Bothrops Jararaca snake venom reduces intraoperative bleeding without influencing the haemostatic balance. Postoperative haematuria could be reduced by antifibrinolytic agents.
This is a preview of subscription content, log in via an institution to check access.
References
Astrup, T., Müllertz, J.: The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem.40, 346 (1952)
Becker, G., Borgström, S., Saltzmann, G.F.: Occurrence and course of thrombosis following prostatectomy. A phlebographic investigation. Acta Radiol.10, 513 (1970)
Cibert, J., Garbit, J.L., Massoumi Mohajder, R., Ogawa, A.: Hémorragies digestives déclenchées par les operations urologiques. J. Urol. Nephrol. (Paris)74, 437 (1958)
Costantini, A., Doni, A., Rizzo, M., Panerai, A., Grechi, G., Bartoletti, L.: Manifestazioni tromboemorragiche di interesse urologico. Atti XLIV Congr. Soc. It. Urol., Venezia 1971
De Nicola, P., Cappelletti, G.A.: I processi di coagulazione e i veleni degli ofidi. Bibl. Haematol.30, 17 (1959)
Denis, R.: Hémorragies de la prostatectomie. J. Urol. Nephrol.78, 475 (1972)
Gallizia, F., Gallizia, G., Francone, E.: Les hémorragies gastrointestinales en chirurgie urologique. J. Urol. Nephrol. (Paris)76, 744 (1970)
Golovsky, D.: Abnormal bleeding after prostatectomy. Med. J. Aust.1, 143 (1973)
Hryntschak, T.: Suprapubic transvescical prostatectomy with primary closure of the bladder. J. Int. Coll. Surg.15, 366 (1951)
Ingram, G.I.C.: The determination of plasma fibrinogen by the clot weight method. Biochem. J.51, 583 (1952)
Kuss, R., Chatelain, C., Jardin, A.: Les hémorragies de l'adénomectomie. J. Urol. Nephrol. (Paris)78, 461 (1972)
Ladehoff, A.A., Rasmussen, J.: Fibronolysis and thromboplastic activity in relation to haemorrhage in transvescical prostatectomy. Scand. J. Clin. Lab. Invest.13, 231 (1961)
Lampugnani, A., Cultrera, G.: Effect of Bothrops Jararaca venom cuagulant fraction on fibrinogen turnover. Il Farmaco25, 985 (1970)
Naeye, R.L.: Thrombotic state after a haemorrhagic diathesis a possible complication of therapy with epsilon-amino caproic acid. Blood19, 694 (1962)
Nilsson, I.M., Olow, B.: Fibrinolysis induced by streptokinase in man. Acta Chir. Scand.123, 247 (1962)
O'Sullivan, E.F.: Abnormal bleeding after prostatectomy: illustrative cases and review of management. Med. J. Aust.2, 1165 (1972)
Pescetto, G., Malagamba, G.: Sul meccanismo di azione del veleno di Bothrops Jararaca (Botropase) e sulle sue indicazioni in campo ginecologico. Bibl. Haematol.30, 173 (1959)
Pontiggia, F., Buttini, G., Giglio, C.: Osservazioni su tre casi di gastroenterorragia secondaria ad interventi urologici. Urologia36, 289 (1969)
Rigondet, C., De Wiart, C.: Les hémorragies primitives et secondaires aprés intervention prostatique rétro-pubienne. J. Urol. Nephrol. (Paris)78, 496 (1972)
Regnon, G., Blondeau, D.: Complications hémorragiques de la prostatectomie. J. Urol. Nephrol. (Paris)78, 488 (1972)
Svensson, A.: Gastrointestinal haemorrhage after prostatectomy. Acta Chir. Scand.133, 229 (1967)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gamba, G., Fornasari, P.M., Grignani, G. et al. Haemostasis during transvesical prostatic adenomectomy. Blut 39, 89–98 (1979). https://doi.org/10.1007/BF01008084
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01008084