Abstract
Norepinephrine, dopamine, and serotonin, as well as the serotonin metabolite, 5-hydroxy-indoleacetic acid, were measured in whole-brain extracts from rats with a portacaval shunt or sham operation. Norepinephrine, serotonin, and 5-hydroxyindoleacetic acid were significantly higher after shunting. There was no difference in dopamine. The results support the idea that brain indole metabolism is increased during chronic hepatic encephalopathy. However, they provide evidence against suggestions that hepatic encephalopathy in general is accompanied by a shortage in the whole-brain content of the catecholamines norepinephrine and dopamine.
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Alsasua, P. A., and Arias, J. (1979). Niveles de catecholamines en distintas estructuras del cerebro de rata tras anastomosis portocava.Arch. Farmacol. Toxicol. V: 97–102.
Baldessarini, R. J., and Fischer, J. E. (1973). Serotonin metabolism in rat brain after surgical diversion of the portal venous circulation.Nature 245: 25–27.
Bernadini, P., and Fischer, J. E. (1982). Amino acid imbalance and hepatic encephalopathy.Annu. Rev. Nutr. 2: 419–454.
Bloch, P., Delorme, M. L., Rapin, J. R., Granger, A., Baschat, M., and Opolon, P. (1978). Reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma.Surg. Gynecol. Obstet. 146: 551–558.
Cuilleret, G., Pomier-Layrargues, G., Pons, F., Cadilhac, J., and Michel, H. (1980). Changes in brain catecholamine levels in human cirrhotic hepatic encephalopathy.Gut 21: 565–569.
Cummings, M. G., Soeters, P. B., James, J. H., Keane, J. M., and Fischer, J. E. (1976a). Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat.J. Neurochem. 27: 501–509.
Cummings, M. G., James, J. H., Soeters, P. B., Keane, J. M., Foster, J., and Fischer, J. E. (1976b). Regional brain study of indoleamine metabolism in the rat in acute hepatic failure.J. Neurochem. 27: 741–746.
Curzon, G., Kantamaneni, B. D., Winch, J., Rojas-Bueno, A., Murray-Lyon, I. M., and Williams, R. (1973). Plasma and brain tryptophan changes in experimental acute hepatic failure.J. Neurochem. 21: 137–145.
Curzon, G., Kantamaneni, B. D., Fernando, J. C., Woods, M. S., and Cavanagh, J. B. (1975). Effect of chronic porta-caval anastomosis on brain tryptophan, tyrosine and 5-hydroxytryptoamine.J. Neurochem. 24: 1065–1070.
Denis, J., Delorme, M. L., Boschat, M., Nordlinger, B., and Opolon, P. (1983). Respective roles of ammonia, amino acids, and medium-sized molecules in the pathogenesis of experimentally induced acute hepatic encephalopathy.J. Neurochem. 40: 10–19.
Dodsworth, J. M., James, J. H., Cummings, M. C., and Fischer, J. E. (1974). Depletion of brain nor-adrenaline in acute hepatic coma.Surgery 75: 811–820.
Elsass, P., Lund, Y., and Ranek, L. (1978). Encephalopathy in patients with cirrhosis of the liver. A neuropsychological study.Scand. J. Gastroenterol. 13: 241–247.
Faraj, B. A., Camp, V. M., Ansley, J. D., Scott, J., Ali, F. M., and Malveaux, E. J. (1981). Evidence for central hypertyraminemia in hepatic encephalopathy.J. Clin. Invest. 67: 395–402.
Fischer, J. E., and Baldessarini, R. J. (1971). False neurotransmitters and hepatic failure.Lancet 2: 75–79.
Fischer, J. E., and Baldessarini, R. J. (1976). Pathogenesis and therapy of hepatic coma. In Popper, H., and Schaffner, F. (eds.),Progress in Liver Diseases, Vol. V, Grune and Stratton, New York, pp. 363–397.
Herlin, P. M., James, J. H., Gimmon, Z., and Fischer, J. E. (1982). Combined or individual administration of branched-chain amino acids following total hepatectomy in the rat: Effects on amino acids and indoleamines in brain.J. Parenter. Enter. Nutr. 6: 383–387.
Hoyumpa, A. M., and Schenker, S. (1982). Perspectives in hepatic encephalopathy.J. Lab. Clin. Med. 100: 477–487.
James, J. H., Hodgeman, J. M., Funovics, J. M., and Fischer, J. E. (1976). Alteration in brain octopamine and brain tyrosine following portacaval anastomosis in rats.J. Neurochem. 27: 223–227.
James, J. H., Jeppsson, B., Zipara, V., and Fischer, J. E. (1979). Hyperammonemia, plasma amino acid imbalance and blood-brain amino acid transport: A unified theory of portal-systemic encephalopathy.Lancet 2: 772–775.
Kamata, S., Okada, A., Watanabe, T., Kawashima, Y., and Wada, H. (1980). Effects of dietary amino acids on brain amino acids and transmitter amines in rats with a portacaval shunt.J. Neurochem. 35: 1190–1199.
Mans, A. M., Biebuyck, J. F., Shelly, K., and Hawkins, R. A. (1982). Regional blood-brain barrier permeability to amino acids after portacaval anastomosis.J. Neurochem. 38: 705–717.
Mans, A. M., Biebuyck, J. F., Davis, D. W., Bryan, R. M., and Hawkins, R. A. (1983). Regional cerebral glucose utilization in rats with portacaval anastomosis.J. Neurochem. 40: 986–991.
Mans, A. M., Biebuyck, J. F., Davis, D. W., and Hawkins, R. A. (1984). Portacaval anastomosis: Brain and plasma amino acid metabolite abnormalities and the effect of nutritional therapy.J. Neurochem. 43: 697–705.
Misra, P. (1981). Hepatic encephalopathy.Med. Clin. No. Am. 65: 209–226.
Munro, H. N., Fernstrom, J. D., and Wurtman, R. J. (1975). Insulin, plasma amino acid imbalance and hepatic coma.Lancet 1: 722–724.
Rehnström, S., Simert, G., Hansson, J. A., Johnson, G., and Vang, J. (1977). Chronic hepatic encephalo-pathy. A psychometrical study.Scand. J. Gastroenterol. 12: 305–311.
Reichle, R. M., and Reichle, F. A. (1975). Effect of portacaval shunt and acute hepatic ischemia on brain and liver serotonin and catecholamines.Surg. Forum 26: 413–415.
Rosen, H. M., Soeters, P. B., James, J. H., Hodgeman, J., and Fischer, J. E. (1978). Influences of exogenous intake and nitrogen balance on plasma and brain aromatic amino acid concentrations.Metabolism 27: 393–404.
Simert, G., Nobin, A., Rosengren, E., and Vang, J. (1978). Neurotransmittor changes in the rat brain after portacaval anastomosis.Eur. Surg. Res. 10: 73–85.
Smith, A. R., Rossi-Fanelli, F., Ziparo, V., James, J. H., Perelle, B. A., and Fischer, J. E. (1978). Alterations in plasma and CSF amino acids, amines and metabolites in hepatic coma.Ann. Surg. 187: 343–350.
Tricklebank, M. D., Smart, J. L., Bloxam, D. L., and Curzon, G. (1978). Effects of chronic experimental liver dysfunction and L-tryptophan on behaviour in the rat.Pharmacol. Biochem. Behav. 9: 181–189.
Tyce, G. M., Flock, E. V., and Owen, C. A. (1967). 5-Hydroxyindole metabolism in the brain after hepatectomy.Biochem. Pharmacol. 16: 979–992.
Warbritton, J. D., III, Geyer, M. A., Jeppsson, B., and Fischer, J. E. (1980). Decreased startle reactivity in the end-to-side portacaval shunted rat.Pharmacol. Biochem. Behav. 12: 739–742.
Zieve, L., and Olsen, R. L. (1977). Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?Gut 18: 688–691.
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Mans, A.M., Hawkins, R.A. Brain monoamines after portacaval anastomosis. Metab Brain Dis 1, 45–52 (1986). https://doi.org/10.1007/BF00998476
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DOI: https://doi.org/10.1007/BF00998476