Abstract
Nineteen patients with newly diagnosed small cell lung cancer (SCLC) were examined with a nanocolloid Tc-99m bone marrow whole body imaging (scintigraphy) in order to detect bone marrow metastasis. Bilateral bone marrow biopsy taken from the posterior iliac crest was used as a reference. The scintigraphy was considered abnormal if a focal lesion was present and/or if the bone marrow activity expanded to more than one-third of the proximal part of the extremities. In 3 of the 19 patients, microscopical bone marrow metastasis and cold spots (focal lesions) on the scintigram were present. An additional 9 patients had expansion of the activity. Eight patients showed scintïgraphic focal lesions in the liver. SCLC metastasis was confirmed in 4 patients, while 1 patient had focal necroses. The results indicate that cold spots rather than expansion of activity with bone marrow scintigraphy detected bone marrow involvement of the disease in patients with SCLC.[/p]
Similar content being viewed by others
References
Green RA, Humphret E, Close H, Patno ME (1969) Alkylating agents in bronchogenic carcinoma. Am J Med 46:616–624
Griner PF, Mayewski RJ, Mushlin AI, Greenland P (1981) Selection and interpretation of diagnostic tests and procedures. Ann Intern Med 94:553–600
Hansen SW, Jensen F, Pedersen NT, Pedersen AG, Hansen HH (1987) Detection of liver metastasis in small-cell lung cancer: a comparison of peritoneoscopy with live biopsy and ultrasonography with fine-needle aspiration. J Clin Oncol 5:255–259
Hirsch FR, Hansen HH (1980) Bone marrow involvement in small-cell anaplastic carcinoma of the lung: prognostic and therapeutic aspects. Cancer 46:205–211
Kessel F, Gamm H, Hahn K (1987) Radionuclide imaging of bone marrow in hematologic systemic disease. Tumour Diagnostik Therapie 8:5–10
Munz DL (1984) Bone marrow imaging: basic concepts and clinical results. Der Nuklearmediziner 7:251–268
Widding A, Smolorz J, Franke M, Linden A, Diehl V, Schicha H (1989) Bone marrow investigation with technetium-99m microcolloid and magnetic resonance imaging in patients with malignant myclolympho-proliferative diseases. Eur J Nucl Med 15:230–238
Yeu-tsu NL (1978) Liver scanning in patients with malignancy: rationale, results and limitation. Cancer Treat Rep 62:1183–1190
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Widding, A., Stilbon, I., Hansen, S.W. et al. Scintigraphy with nanocolloid Tc 99m in patients with small cell lung cancer, with special reference to bone marrow and hepatic metastasis. Eur J Nucl Med 16, 717–719 (1990). https://doi.org/10.1007/BF00998176
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00998176