Skip to main content
SpringerLink
Log in

Metabolism of3H-digoxin and some acetyl-digoxins: Time-dependent formation of hydrophilic metabolites after oral application in man

  • Short Communication
  • Published:
Naunyn-Schmiedebergs Archiv für Pharmakologie Aims and scope Submit manuscript

Summary

After oral administration of3H-digoxin,3H-β(= 16′)-acetyldigoxin,3H-α(=15′)-acetyldigoxin and3H-(15′,16′)-diacetyldigoxin water-soluble metabolites have been found in the urine of three persons. A maximum is reached after 4–5 h. These metabolites are very polar and are not identical with neither digoxigenin nor with its mono- and bis-digitoxosides.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Haberland, G., Maerten, G.: Spezifischer Deuterium- und Tritium-Austausch in Cardenoliden und Cardenolidglykosiden. Naturwissenschaften10, 516 (1969).

    Google Scholar 

  • Marcus, F. I., Burkhalter, L., Cuccia, C., Pavlovich, J., Kapadia, G. G.: Administration of tritiated digoxin with and without a loading dose. Circulation34, 865 (1966a).

    Google Scholar 

  • —, Kapadia, G. J., Kapadia, G. G.: The metabolism of digoxin in normal subjects. J. Pharmacol. exp. Ther.145, 203 (1964).

    Google Scholar 

  • —, Peterson, A., Salel, A., Scully, J., Kapadia, G. G.: The metabolism of tritiated digoxin in renal insufficiency in dogs and man. J. Pharmacol. exp. Ther.152, 372 (1966b).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Laboratories of Fa. Beiersdorf AG, Hamburg

    A. Dwenger & G. Haberland

Authors
  1. A. Dwenger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Haberland
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dwenger, A., Haberland, G. Metabolism of3H-digoxin and some acetyl-digoxins: Time-dependent formation of hydrophilic metabolites after oral application in man. Naunyn-Schmiedebergs Arch. Pharmak. 270, 102–104 (1971). https://doi.org/10.1007/BF00997306

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00997306

Key-words

Search

Navigation