Summary
One hundred and forty-five children aged 3 months to 11.5 years, with rectal temperatures greater than 38.9°C, were randomly treated with aspirin 5, 10 or 15 mg/kg p.o. Temperatures were recorded just before medication, every 30 min thereafter for 4 h and subsequently hourly up to 6 h. In all dosage regimens the average temperature was significantly reduced in the time interval 1–6 h after drug administration; the antipyretic effect, however, was significantly greater with the 10 and 15 mg/kg doses. Both had significantly better and comparable clinical efficacy, defined as reduction in fever below 38.9°C. The duration of the clinical effect was not dose-related. A dose of 10 mg/kg appears rational for the treatment of children with fever.
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Vigano, A., Dalla Villa, A., Cecchini, I. et al. Correlation between dosage and antipyretic effect of aspirin in children. Eur J Clin Pharmacol 31, 359–361 (1986). https://doi.org/10.1007/BF00981138
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DOI: https://doi.org/10.1007/BF00981138