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Myo-inositol transport through the blood-brain barrier

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Abstract

The unidirectional transport of [3H]myo-inositol across cerebral capillaries, the anatomical locus of the blood-brain barrier, was measured using an in situ rat brain perfusion technique. Myo-inositol was transported across the blood-brain barrier by a low capacity, saturable system with a one-half saturation concentration of ∼0.1 mM. The permeability surface-area product was 6.2×10−5S−1 with a myo-inositol concentration of 0.02 mM in the perfusate. The myo-inositol stereoisomer scyllo-inositol but not (+)-chiro-inositol (both 1 mM) inhibited myo-inositol transfer through the blood-brain barrier. These observations provide evidence that myo-inositol is transferred through the blood-brain barrier by simple diffusion and a stereospecific, saturable transport system.

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Authors and Affiliations

  1. Department of Internal Medicine and Pharmacology, University of Iowa College of Medicine, 52242, Iowa City, IA

    Reynold Spector (Executive Director, Clinical Sciences)

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  1. Reynold Spector
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Spector, R. Myo-inositol transport through the blood-brain barrier. Neurochem Res 13, 785–787 (1988). https://doi.org/10.1007/BF00971603

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  • DOI: https://doi.org/10.1007/BF00971603

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